CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

Markus Kleinewietfeld, Fabiola Puentes, Giovanna Borsellino, Luca Battistini, Olaf Rötzschke, Kirsten Falk

Research output: Contribution to journalArticlepeer-review


Regulatory CD25+CD4+ T cells (Treg cells) are a central element of peripheral tolerance. Little is known, however, about phenotypic and functional characteristics of these cells with regard to memory. In this study we show that the chemokine receptor CCR6 is expressed on a distinct subset of mouse Treg cells. Similar to their CD25- counterparts, CCR6+ Treg cells exhibit markers of activation, memory, and expansion that are indicative for an effector-memory function. They are memory-like cells, generated in vivo from CCR6-CD25+ T cells after the encounter of antigen. As conventional CD25- effector-memory T cells, they have a high turnover rate and, in contrast to CCR6- Treg cells, they respond rapidly to restimulation in vitro with up-regulation of interleukin 10. CCR6+ Treg cells are enriched in the peripheral blood and accumulate in the central nervous system after induction of experimental autoimmune encephalomyelitis (EAE). This subset therefore seems to represent a population of regulatory effector-memory T cells (TREM), destined to control potentially destructive immune responses directly in inflamed tissues. Importantly, these cells are also present in humans. Here the expression of CCR6 fully cosegregates with CD45RO, an established marker of human memory T cells.

Original languageEnglish
Pages (from-to)2877-2886
Number of pages10
Issue number7
Publication statusPublished - Apr 1 2005

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset'. Together they form a unique fingerprint.

Cite this