TY - JOUR
T1 - CC chemokine receptor 5 polymorphism in Italian patients with Beḩet's disease
AU - Atzeni, Fabiola
AU - Boiardi, Luigi
AU - Casali, Bruno
AU - Farnetti, Enrico
AU - Nicoli, Davide
AU - Sarzi-puttini, Piercarlo
AU - Pipitone, Nicolò
AU - Olivieri, Ignazio
AU - Cantini, Fabrizio
AU - Salvi, Fabrizio
AU - La corte, Renato
AU - Triolo, Giovanni
AU - Filippini, Davide
AU - Paolazzi, Giuseppe
AU - Salvarani, Carlo
PY - 2012/12
Y1 - 2012/12
N2 - Objective: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to and clinical expression of Beḩet's disease (BD) in a cohort of Italian patients. Methods: One hundred and ninety-six consecutive Italian patients satisfying the ISG criteria for BD were followed up for 8 years, and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. A standard microlymphocytotoxicity technique was used to serotype HLA-B51. The patients were subgrouped on the basis of the presence or absence of clinical manifestations. Results: The distribution of the CCR5Δ32 genotype differed between BD patients and controls (P = 0.02). The CCR5Δ32 allele was more common in BD patients than in controls [P = 0.02, odds ratio (OR) 2.28 (95% CI 1.1, 4.8)]. Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were significantly more common in BD patients than in controls [P = 0.02, OR 2.37 (95% CI 1.1, 5.1)]. Population-attributable risk was 7.1%. In categorizing patients according to gender, the association between CCR5Δ32 polymorphism and BD was similar in females and males (ORs 2.76 and 2.0, respectively). No significant differences were found when the frequencies of clinical manifestations were compared between CC5RΔ32 allele carriers and non-carriers. Conclusion: CCR5Δ32 polymorphism is associated with an increased susceptibility to develop BD. Chemokines may have a role in the pathophysiology of BD.
AB - Objective: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to and clinical expression of Beḩet's disease (BD) in a cohort of Italian patients. Methods: One hundred and ninety-six consecutive Italian patients satisfying the ISG criteria for BD were followed up for 8 years, and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. A standard microlymphocytotoxicity technique was used to serotype HLA-B51. The patients were subgrouped on the basis of the presence or absence of clinical manifestations. Results: The distribution of the CCR5Δ32 genotype differed between BD patients and controls (P = 0.02). The CCR5Δ32 allele was more common in BD patients than in controls [P = 0.02, odds ratio (OR) 2.28 (95% CI 1.1, 4.8)]. Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were significantly more common in BD patients than in controls [P = 0.02, OR 2.37 (95% CI 1.1, 5.1)]. Population-attributable risk was 7.1%. In categorizing patients according to gender, the association between CCR5Δ32 polymorphism and BD was similar in females and males (ORs 2.76 and 2.0, respectively). No significant differences were found when the frequencies of clinical manifestations were compared between CC5RΔ32 allele carriers and non-carriers. Conclusion: CCR5Δ32 polymorphism is associated with an increased susceptibility to develop BD. Chemokines may have a role in the pathophysiology of BD.
KW - Beḩet's disease
KW - CC chemokine receptor 5 Δ32 olymorphism
KW - Chemokines
KW - Disease manifestations
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U2 - 10.1093/rheumatology/kes238
DO - 10.1093/rheumatology/kes238
M3 - Article
C2 - 22966075
AN - SCOPUS:84870355384
SN - 1462-0324
VL - 51
SP - 2141
EP - 2145
JO - Rheumatology
JF - Rheumatology
IS - 12
M1 - kes238
ER -