Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease

Tiziana Ingegni; Giuseppe Nocentini; Elena Mariani; Liana Spazzafumo; M. Cristina polidori; Antonio Cherubini; Marco Catani; Donatella Cadini; Umberto Senin; Patrizia Mecocci

doi:10.1159/000071003

Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease

Tiziana Ingegni, Giuseppe Nocentini, Elena Mariani, Liana Spazzafumo, M. Cristina polidori, Antonio Cherubini, Marco Catani, Donatella Cadini, Umberto Senin, Patrizia Mecocci

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Alzheimer's disease (AD) is the most frequent cause of dementia in elderly people. Different pathological pathways have been involved in the development of late-onset AD. Among them, numerous genes have been proposed as pathogenetic factors acting independently or interactively. It has been suggested that the cathepsin D gene (CTSD) is associated with late-onset AD. We analyzed an exonic polymorphism of the CTSD gene [C→T (Ala→Val) transition at position 224] in 142 AD patients and 120 controls. Our data indicate no significant association between this polymorphism and the risk of AD. Likewise there was no association between CTSD polymorphism and the apolipoprotein E genotype in the risk of developing AD.

Original language	English
Pages (from-to)	151-155
Number of pages	5
Journal	Dementia and Geriatric Cognitive Disorders
Volume	16
Issue number	3
DOIs	https://doi.org/10.1159/000071003
Publication status	Published - 2003

Keywords

Alzheimer's disease
Apolipoprotein E
Cathepsin D
Genetics
Polymorphism

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Geriatrics and Gerontology

Access to Document

10.1159/000071003

Cite this

@article{d9a34d5525804ad19ace7724ebd2afbd,

title = "Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease",

abstract = "Alzheimer's disease (AD) is the most frequent cause of dementia in elderly people. Different pathological pathways have been involved in the development of late-onset AD. Among them, numerous genes have been proposed as pathogenetic factors acting independently or interactively. It has been suggested that the cathepsin D gene (CTSD) is associated with late-onset AD. We analyzed an exonic polymorphism of the CTSD gene [C→T (Ala→Val) transition at position 224] in 142 AD patients and 120 controls. Our data indicate no significant association between this polymorphism and the risk of AD. Likewise there was no association between CTSD polymorphism and the apolipoprotein E genotype in the risk of developing AD.",

keywords = "Alzheimer's disease, Apolipoprotein E, Cathepsin D, Genetics, Polymorphism",

author = "Tiziana Ingegni and Giuseppe Nocentini and Elena Mariani and Liana Spazzafumo and polidori, {M. Cristina} and Antonio Cherubini and Marco Catani and Donatella Cadini and Umberto Senin and Patrizia Mecocci",

year = "2003",

doi = "10.1159/000071003",

language = "English",

volume = "16",

pages = "151--155",

journal = "Dementia and Geriatric Cognitive Disorders",

issn = "1420-8008",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease

AU - Ingegni, Tiziana

AU - Nocentini, Giuseppe

AU - Mariani, Elena

AU - Spazzafumo, Liana

AU - polidori, M. Cristina

AU - Cherubini, Antonio

AU - Catani, Marco

AU - Cadini, Donatella

AU - Senin, Umberto

AU - Mecocci, Patrizia

PY - 2003

Y1 - 2003

N2 - Alzheimer's disease (AD) is the most frequent cause of dementia in elderly people. Different pathological pathways have been involved in the development of late-onset AD. Among them, numerous genes have been proposed as pathogenetic factors acting independently or interactively. It has been suggested that the cathepsin D gene (CTSD) is associated with late-onset AD. We analyzed an exonic polymorphism of the CTSD gene [C→T (Ala→Val) transition at position 224] in 142 AD patients and 120 controls. Our data indicate no significant association between this polymorphism and the risk of AD. Likewise there was no association between CTSD polymorphism and the apolipoprotein E genotype in the risk of developing AD.

AB - Alzheimer's disease (AD) is the most frequent cause of dementia in elderly people. Different pathological pathways have been involved in the development of late-onset AD. Among them, numerous genes have been proposed as pathogenetic factors acting independently or interactively. It has been suggested that the cathepsin D gene (CTSD) is associated with late-onset AD. We analyzed an exonic polymorphism of the CTSD gene [C→T (Ala→Val) transition at position 224] in 142 AD patients and 120 controls. Our data indicate no significant association between this polymorphism and the risk of AD. Likewise there was no association between CTSD polymorphism and the apolipoprotein E genotype in the risk of developing AD.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Cathepsin D

KW - Genetics

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=0038454936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038454936&partnerID=8YFLogxK

U2 - 10.1159/000071003

DO - 10.1159/000071003

M3 - Article

C2 - 12826741

AN - SCOPUS:0038454936

SN - 1420-8008

VL - 16

SP - 151

EP - 155

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 3

ER -

Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this