TY - JOUR
T1 - Cancer rejection by the immune system
T2 - Forcing the check-points of tumor immune escape
AU - Mocellin, Simone
AU - Mandruzzato, Susanna
AU - Zanovello, Paola
AU - Bronte, Vincenzo
PY - 2005
Y1 - 2005
N2 - Although the immune system can recognize and kill malignant cells, tumor immune surveillance or immunotherapy are largely insufficient in controlling cancer. The mechanisms underlying tumor immune escape are still to be fully dissected. An important emerging concept is that tumor and tumor-infiltrating host cells can alter the metabolism of some amino acids with a profound impact on antitumor immunity. Such mechanisms constitute potential check-points for tumor-specific T-lymphocytes, which must be considered in the design of novel immunotherapeutic approaches.
AB - Although the immune system can recognize and kill malignant cells, tumor immune surveillance or immunotherapy are largely insufficient in controlling cancer. The mechanisms underlying tumor immune escape are still to be fully dissected. An important emerging concept is that tumor and tumor-infiltrating host cells can alter the metabolism of some amino acids with a profound impact on antitumor immunity. Such mechanisms constitute potential check-points for tumor-specific T-lymphocytes, which must be considered in the design of novel immunotherapeutic approaches.
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U2 - 10.1016/j.ddmec.2005.05.016
DO - 10.1016/j.ddmec.2005.05.016
M3 - Article
AN - SCOPUS:33645085286
SN - 1740-6765
VL - 2
SP - 191
EP - 197
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 2
ER -