Cancer of pancreas

Filippo De Braud, Stefano Cascinu, Gemma Gatta

Research output: Contribution to journalArticlepeer-review


Cancer of the pancreas is the tenth most frequent cancer in Europe, accounting for some 3% of cancer in both sex. Smoking has been clearly established as a major risk factor affecting the carcinogenesis of pancreatic carcinoma. Diet has also been associated with pancreatic cancer, although no conclusive data are yet available. Different genetic alterations have been observed in pancreatic neoplasms. Typical symptoms of pancreatic cancer are: jaundice, abdominal pain and weight loss. The prognosis of pancreatic carcinoma depends mainly on radical surgery and the presence of negative resection margins, as well as on the biological tumour stage, which also influences the treatment strategy. The treatment of pancreatic cancer is undertaken with two aims. Radical surgery is indicated for patients with early stage of disease, mainly stage I and partially II. In all other cases, the aim of treatment is the palliation of different very distressing symptoms related to this neoplasm.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Issue number2
Publication statusPublished - May 2004


  • Carcinoma
  • Jaundice
  • Neoplasm

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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