Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols

M. Kogevinas; R. Saracci; P. A. Bertazzi; B. H Bueno de Mesquita; D. Coggon; L. M. Green; T. Kauppinen; M. Littorin; E. Lynge; J. D. Mathews; M. Neuberger; J. Osman; N. Pearce; R. Winkelmann

doi:10.1016/0045-6535(92)90109-5

Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols

M. Kogevinas, R. Saracci, P. A. Bertazzi, B. H Bueno de Mesquita, D. Coggon, L. M. Green, T. Kauppinen, M. Littorin, E. Lynge, J. D. Mathews, M. Neuberger, J. Osman, N. Pearce, R. Winkelmann

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

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Abstract

Mortality from soft-tissue sarcoma and malignant lymphomas was examined in an international register including 18,910 production workers or sprayers from 10 countries. Exposure to chlorophenoxy herbicides and chlorophenols was evaluated from job histories in conjunction with information collected through company questionnaires and other exposure related documents. No excess was observed for malignant lymphomas. A two-fold excess risk, based on four observed deaths, was observed overall for soft-tissue sarcoma; the risk was concentrated as an about six-fold statistically significant excess, occurring 10 to 19 years from first exposure in the cohort as a whole, and was highest among sprayers. In the present set of data the excess does not appear specifically associated with those chlorophenoxy herbicides probably contaminated by TCDD.

Original language	English
Pages (from-to)	1071-1076
Number of pages	6
Journal	Chemosphere
Volume	25
Issue number	7-10
DOIs	https://doi.org/10.1016/0045-6535(92)90109-5
Publication status	Published - 1992

ASJC Scopus subject areas

Environmental Science(all)
Environmental Chemistry

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Kogevinas, M., Saracci, R., Bertazzi, P. A., de Mesquita, B. H. B., Coggon, D., Green, L. M., Kauppinen, T., Littorin, M., Lynge, E., Mathews, J. D., Neuberger, M., Osman, J., Pearce, N., & Winkelmann, R. (1992). Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols. Chemosphere, 25(7-10), 1071-1076. https://doi.org/10.1016/0045-6535(92)90109-5

Kogevinas, M, Saracci, R, Bertazzi, PA, de Mesquita, BHB, Coggon, D, Green, LM, Kauppinen, T, Littorin, M, Lynge, E, Mathews, JD, Neuberger, M, Osman, J, Pearce, N & Winkelmann, R 1992, 'Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols', Chemosphere, vol. 25, no. 7-10, pp. 1071-1076. https://doi.org/10.1016/0045-6535(92)90109-5

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title = "Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols",

abstract = "Mortality from soft-tissue sarcoma and malignant lymphomas was examined in an international register including 18,910 production workers or sprayers from 10 countries. Exposure to chlorophenoxy herbicides and chlorophenols was evaluated from job histories in conjunction with information collected through company questionnaires and other exposure related documents. No excess was observed for malignant lymphomas. A two-fold excess risk, based on four observed deaths, was observed overall for soft-tissue sarcoma; the risk was concentrated as an about six-fold statistically significant excess, occurring 10 to 19 years from first exposure in the cohort as a whole, and was highest among sprayers. In the present set of data the excess does not appear specifically associated with those chlorophenoxy herbicides probably contaminated by TCDD.",

author = "M. Kogevinas and R. Saracci and Bertazzi, {P. A.} and {de Mesquita}, {B. H Bueno} and D. Coggon and Green, {L. M.} and T. Kauppinen and M. Littorin and E. Lynge and Mathews, {J. D.} and M. Neuberger and J. Osman and N. Pearce and R. Winkelmann",

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doi = "10.1016/0045-6535(92)90109-5",

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T1 - Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols

AU - Kogevinas, M.

AU - Saracci, R.

AU - Bertazzi, P. A.

AU - de Mesquita, B. H Bueno

AU - Coggon, D.

AU - Green, L. M.

AU - Kauppinen, T.

AU - Littorin, M.

AU - Lynge, E.

AU - Mathews, J. D.

AU - Neuberger, M.

AU - Osman, J.

AU - Pearce, N.

AU - Winkelmann, R.

PY - 1992

Y1 - 1992

N2 - Mortality from soft-tissue sarcoma and malignant lymphomas was examined in an international register including 18,910 production workers or sprayers from 10 countries. Exposure to chlorophenoxy herbicides and chlorophenols was evaluated from job histories in conjunction with information collected through company questionnaires and other exposure related documents. No excess was observed for malignant lymphomas. A two-fold excess risk, based on four observed deaths, was observed overall for soft-tissue sarcoma; the risk was concentrated as an about six-fold statistically significant excess, occurring 10 to 19 years from first exposure in the cohort as a whole, and was highest among sprayers. In the present set of data the excess does not appear specifically associated with those chlorophenoxy herbicides probably contaminated by TCDD.

AB - Mortality from soft-tissue sarcoma and malignant lymphomas was examined in an international register including 18,910 production workers or sprayers from 10 countries. Exposure to chlorophenoxy herbicides and chlorophenols was evaluated from job histories in conjunction with information collected through company questionnaires and other exposure related documents. No excess was observed for malignant lymphomas. A two-fold excess risk, based on four observed deaths, was observed overall for soft-tissue sarcoma; the risk was concentrated as an about six-fold statistically significant excess, occurring 10 to 19 years from first exposure in the cohort as a whole, and was highest among sprayers. In the present set of data the excess does not appear specifically associated with those chlorophenoxy herbicides probably contaminated by TCDD.

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JF - Chemosphere

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Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols

Abstract

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