Abstract
Tumor microenvironment plays an important role in cancer initiation and progression. In hematological malignancies, the bone marrow represents the paradigmatic anatomical site in which tumor microenvironment expresses its morphofunctional features. Among the cells participating in the composition of this microenvironment, cancer associated fibrobasts (CAFs) have received less attention in hematopoietic tumors compared to solid cancers. In this review article, we discuss the involvement of CAFs in progression of hematological malignancies and the potential targeting of CAFs in a therapeutic perspective.
| Original language | English |
|---|---|
| Pages (from-to) | 2589-2603 |
| Number of pages | 15 |
| Journal | Oncotarget |
| Volume | 6 |
| Issue number | 5 |
| Publication status | Published - 2015 |
Keywords
- Cancer associated fibroblasts
- Hematological malignancies
- Mesenchymal stromal cells
- Tumor microenvironment
ASJC Scopus subject areas
- Oncology