TY - JOUR
T1 - Calorie Restriction for Optimal Cardiovascular Aging
T2 - The Weight of Evidence
AU - Marzetti, Emanuele
AU - Wohlgemuth, Stephanie E.
AU - Aulisa, Angelo G.
AU - Bernabei, Roberto
AU - Pahor, Marco
AU - Leeuwenburgh, Christiaan
PY - 2010
Y1 - 2010
N2 - The epidemic of obesity and overweight is spreading worldwide. Excessive adiposity is associated with a myriad of adverse health outcomes, leading to increased health care expenditures and shortened life expectancy. In contrast to overeating, calorie restriction (CR), defined as a reduction in food intake without malnutrition, increases both mean and maximum lifespan in a variety of species by reducing the incidence of several chronic degenerative diseases, including cardiovascular disease. The constellation of health benefits brought about by CR results from biological and physiologic changes affecting fundamental processes underlying aging and age-related pathologies. Despite the beneficial properties of CR, it is likely that most people will not engage in such a dietary regimen for the long-term. Supplementation with specific compounds mimicking CR may represent a more feasible means to improve health and prolong life. However, evidence on long-term effectiveness and safety of these compounds is not yet available in humans.
AB - The epidemic of obesity and overweight is spreading worldwide. Excessive adiposity is associated with a myriad of adverse health outcomes, leading to increased health care expenditures and shortened life expectancy. In contrast to overeating, calorie restriction (CR), defined as a reduction in food intake without malnutrition, increases both mean and maximum lifespan in a variety of species by reducing the incidence of several chronic degenerative diseases, including cardiovascular disease. The constellation of health benefits brought about by CR results from biological and physiologic changes affecting fundamental processes underlying aging and age-related pathologies. Despite the beneficial properties of CR, it is likely that most people will not engage in such a dietary regimen for the long-term. Supplementation with specific compounds mimicking CR may represent a more feasible means to improve health and prolong life. However, evidence on long-term effectiveness and safety of these compounds is not yet available in humans.
KW - Apoptosis
KW - Hormesis
KW - Inflammation
KW - Obesity
KW - Oxidative stress
KW - Sirtuins
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U2 - 10.1007/s12170-010-0114-8
DO - 10.1007/s12170-010-0114-8
M3 - Article
AN - SCOPUS:84873511409
SN - 1932-9520
VL - 4
SP - 340
EP - 346
JO - Current Cardiovascular Risk Reports
JF - Current Cardiovascular Risk Reports
IS - 5
ER -