TY - JOUR
T1 - CA 125 in serum, peritoneal fluid, active lesions, and endometrium of patients with endometriosis
AU - Fedele, Luigi
AU - Vercellini, Paolo
AU - Arcaini, Luisa
AU - Grazia da Dalt, Maria
AU - Candiani, Giovanni B.
PY - 1988
Y1 - 1988
N2 - Ca 125 levels in serum and peritoneal fluid were measured in 39 patients with endometriosis and 18 patients with normal pelvic anatomy at laparoscopy, and the presence of this antigen in endometriotic tissue and endometrial mucosa was also investigated. Serum CA 125 concentrations were elevated in patients with Stage III or IV endometriosis compared with control subjects (32.9 ± 11.2 versus 16.4 ± 8.9 U/ml, means ± SD; p <0.001). CA 125 values were >35 U/ml in 36.8% of women with Stage III or IV endometriosis and in none of the control subjects. No significant differences in CA 125 levels in peritoneal fluid were found between patients with endometriosis and control subjects. The immunohistochemical studies found CA 125 in 10% of the endometriotic lesions and 37.5% of the endometrial samples of patients with endometriosis and in 33.3% of the endometrial samples of control subjects.
AB - Ca 125 levels in serum and peritoneal fluid were measured in 39 patients with endometriosis and 18 patients with normal pelvic anatomy at laparoscopy, and the presence of this antigen in endometriotic tissue and endometrial mucosa was also investigated. Serum CA 125 concentrations were elevated in patients with Stage III or IV endometriosis compared with control subjects (32.9 ± 11.2 versus 16.4 ± 8.9 U/ml, means ± SD; p <0.001). CA 125 values were >35 U/ml in 36.8% of women with Stage III or IV endometriosis and in none of the control subjects. No significant differences in CA 125 levels in peritoneal fluid were found between patients with endometriosis and control subjects. The immunohistochemical studies found CA 125 in 10% of the endometriotic lesions and 37.5% of the endometrial samples of patients with endometriosis and in 33.3% of the endometrial samples of control subjects.
KW - CA 125
KW - external endometriosis
KW - Tumor marker
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U2 - 10.1016/0002-9378(88)90803-4
DO - 10.1016/0002-9378(88)90803-4
M3 - Article
C2 - 3422132
AN - SCOPUS:0023854807
SN - 0002-9378
VL - 158
SP - 166
EP - 170
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -