Built-in software in children on long-term ventilation in real life practice

Alessandro Onofri, Martino Pavone, Simone De Santis, Elisabetta Verrillo, Serena Caggiano, Nicola Ullmann, Maria Giovanna Paglietti, Beatrice Chiarini Testa, Renato Cutrera

Research output: Contribution to journalArticlepeer-review


Information gathered with built-in software (BIS) on new ventilators allow clinicians to access long-term noninvasive ventilation (LTNIV) data. Nevertheless, few evidence are available in literature that highlight potential strengths and disadvantages of using BIS in pediatrics. We aim to evaluate the use of BIS in a cohort of 90 children on LTNIV in our unit, focusing mainly on adherence, air leaks, and residual sleep events. We found that caregivers' perception of ventilator use is independent from objective adherence (P =.137). Furthermore, we failed to find any predictors of adherence. As regards air leaks, we found that pre-scholars' (0-6 years old) total air leaks are lower than teenagers' (more than 12 years old) (P <.05). Multiple regressive analysis showed that age at the beginning of therapy is a predictor of total air leaks: prescholars are associated with lower values (P <.05), while scholars (6-12 years old) are associated with higher values (P <.05). Finally, we explored the validity of BIS automatic scoring of sleep events (AHIBIS) as compared with the manual scoring of polygraphy (AHIPG). AHIBIS is within a range of 3.98 from AHIPG in 95% of cases, with a 64% of sensitivity and a 67% of specificity in identifying a pathological state. The disagreement between the two methods seems to increase for high AHI values. In conclusion, data gathered by BIS are a useful support tool for the clinician in assessing the course of LTNIV. However, clinicians must be aware of the several limitations of built-in software, especially in pediatrics.

Original languageEnglish
Pages (from-to)2697-2705
Number of pages9
JournalPediatric Pulmonology
Issue number10
Publication statusPublished - Oct 1 2020


  • mechanical ventilation
  • noninvasive ventilation
  • respiratory technology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Built-in software in children on long-term ventilation in real life practice'. Together they form a unique fingerprint.

Cite this