Abstract
The compensation of the different level of transcripts of X-linked genes in male and female mammals is achieved through X chromosome inactivation, a complex process that differentially regulates the sex chromosomes of female cells. This mechanism has been dissected at evolutionary, genetic and molecular levels: here, we discuss some of the latest examples that illustrate better these intricate connections, focusing particularly on the emerging role of spatial and three-dimensional chromatin arrangements in the building of this special chromosome, the inactive X chromosome.
| Original language | English |
|---|---|
| Pages (from-to) | 63-70 |
| Number of pages | 8 |
| Journal | Biology of the cell / under the auspices of the European Cell Biology Organization |
| Volume | 100 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
Keywords
- Epigenetic mechanism
- Nuclear architecture
- Pseudoautosomal region 2 (PAR2)
- X chromosome inactivation
- X-inactive-specific transcript
ASJC Scopus subject areas
- Cell Biology