Brief report: Prognostic importance of cellular DNA content in T1-2 no laryngeal squamous cell carcinomas treated with radiotherapy

Giuseppe Toffoli; Giovanni Franchin; Luigi Barzan; Claudia Cernigoi; Antonino Carbone; Sandro Sulfaro; Silvia Franceschi; Mauro Boiocchi

Brief report: Prognostic importance of cellular DNA content in T1-2 no laryngeal squamous cell carcinomas treated with radiotherapy

Giuseppe Toffoli, Giovanni Franchin, Luigi Barzan, Claudia Cernigoi, Antonino Carbone, Sandro Sulfaro, Silvia Franceschi, Mauro Boiocchi

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

One hundred fifty-two unselected, consecutive patients with T1-2N0 laryngeal squamous cell carcinoma received radical radiation therapy at the Division of Radiotherapy, Centro di Riferimento Oncologico, Aviano, Italy. Thirty-one (20.4%) of the patients showed disease recurrence or persistence (R/P) after radiotherapy. Flow-cytometric DNA ploidy measurements were performed in 72 cases; 20 had tumor R/P and 52 did not. Tumor R/P occurred more frequently (in 17 [85%] of 20 cases) in patients with diploid tumors. The hazard ratio of recurrence in diploid tumors as compared with aneuploid tumors, after inclusion of all the other significant prognostic factors in a Cox proportional hazards model, was 8.9 (P

Original language	English
Pages (from-to)	649-652
Number of pages	4
Journal	Laryngoscope
Volume	105
Issue number	6
Publication status	Published - 1995

ASJC Scopus subject areas

Otorhinolaryngology

Cite this

@article{09db5f848df44c4eadc48f10941e4dc3,

title = "Brief report: Prognostic importance of cellular DNA content in T1-2 no laryngeal squamous cell carcinomas treated with radiotherapy",

abstract = "One hundred fifty-two unselected, consecutive patients with T1-2N0 laryngeal squamous cell carcinoma received radical radiation therapy at the Division of Radiotherapy, Centro di Riferimento Oncologico, Aviano, Italy. Thirty-one (20.4%) of the patients showed disease recurrence or persistence (R/P) after radiotherapy. Flow-cytometric DNA ploidy measurements were performed in 72 cases; 20 had tumor R/P and 52 did not. Tumor R/P occurred more frequently (in 17 [85%] of 20 cases) in patients with diploid tumors. The hazard ratio of recurrence in diploid tumors as compared with aneuploid tumors, after inclusion of all the other significant prognostic factors in a Cox proportional hazards model, was 8.9 (P",

author = "Giuseppe Toffoli and Giovanni Franchin and Luigi Barzan and Claudia Cernigoi and Antonino Carbone and Sandro Sulfaro and Silvia Franceschi and Mauro Boiocchi",

year = "1995",

language = "English",

volume = "105",

pages = "649--652",

journal = "Laryngoscope",

issn = "0023-852X",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Brief report

T2 - Prognostic importance of cellular DNA content in T1-2 no laryngeal squamous cell carcinomas treated with radiotherapy

AU - Toffoli, Giuseppe

AU - Franchin, Giovanni

AU - Barzan, Luigi

AU - Cernigoi, Claudia

AU - Carbone, Antonino

AU - Sulfaro, Sandro

AU - Franceschi, Silvia

AU - Boiocchi, Mauro

PY - 1995

Y1 - 1995

N2 - One hundred fifty-two unselected, consecutive patients with T1-2N0 laryngeal squamous cell carcinoma received radical radiation therapy at the Division of Radiotherapy, Centro di Riferimento Oncologico, Aviano, Italy. Thirty-one (20.4%) of the patients showed disease recurrence or persistence (R/P) after radiotherapy. Flow-cytometric DNA ploidy measurements were performed in 72 cases; 20 had tumor R/P and 52 did not. Tumor R/P occurred more frequently (in 17 [85%] of 20 cases) in patients with diploid tumors. The hazard ratio of recurrence in diploid tumors as compared with aneuploid tumors, after inclusion of all the other significant prognostic factors in a Cox proportional hazards model, was 8.9 (P

AB - One hundred fifty-two unselected, consecutive patients with T1-2N0 laryngeal squamous cell carcinoma received radical radiation therapy at the Division of Radiotherapy, Centro di Riferimento Oncologico, Aviano, Italy. Thirty-one (20.4%) of the patients showed disease recurrence or persistence (R/P) after radiotherapy. Flow-cytometric DNA ploidy measurements were performed in 72 cases; 20 had tumor R/P and 52 did not. Tumor R/P occurred more frequently (in 17 [85%] of 20 cases) in patients with diploid tumors. The hazard ratio of recurrence in diploid tumors as compared with aneuploid tumors, after inclusion of all the other significant prognostic factors in a Cox proportional hazards model, was 8.9 (P

UR - http://www.scopus.com/inward/record.url?scp=0029019729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029019729&partnerID=8YFLogxK

M3 - Article

C2 - 7769952

AN - SCOPUS:0029019729

SN - 0023-852X

VL - 105

SP - 649

EP - 652

JO - Laryngoscope

JF - Laryngoscope

IS - 6

ER -

Brief report: Prognostic importance of cellular DNA content in T1-2 no laryngeal squamous cell carcinomas treated with radiotherapy

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this