Breast density assessment using a 3T MRI system: Comparison among different sequences

Alberto Tagliafico, Bianca Bignotti, Giulio Tagliafico, Davide Astengo, Lucia Martino, Sonia Airaldi, Alessio Signori, Maria Pia Sormani, Nehmat Houssami, Massimo Calabrese

Research output: Contribution to journalArticlepeer-review


Purpose: To compare MRI sequences for breast density measurements on a 3T MRI system using IDEAL (Iterative Decomposition of water and fat with Echo Asymmetry and Least squares estimation) as possible physiology-like reference. Materials and Methods: MRI examination was performed in 48 consecutive patients (mean age 41, years; range, 35-67 years) on a 3.0T scanner and 46 were included. All (fertile) women, were examined between days 5 and 15 of their menstrual cycle. MRI protocol included: T1-turbo spin-echo (T1-tSE), T2-turbo spin-echo (T2-tSE), VIBRANT (Volume Imaging for Breast Assessment) before and after injection of contrast media and IDEAL. Breast density was calculated with semi-automated software. Statistical analysis was performed with non-parametric tests. Results: Mean percentage of breast density calculated in each sequence was: T1-tSE = 56%; T2-tSE = 52%; IDEAL FatOnly = 55%; IDEAL WaterOnly = 53%, VIBRANT = 55%. Significant differences were observed between T2-tSE and both T1-tSE (p

Original languageEnglish
Article numbere99027
JournalPLoS One
Issue number6
Publication statusPublished - Jun 3 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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