Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Tess V Clendenen; Wenzhen Ge; Karen L Koenig; Yelena Afanasyeva; Claudia Agnoli; Elizabeth Bertone-Johnson; Louise A Brinton; Farbod Darvishian; Joanne F Dorgan; A Heather Eliassen; Roni T Falk; Göran Hallmans; Susan E Hankinson; Judith Hoffman-Bolton; Timothy J Key; Vittorio Krogh; Hazel B Nichols; Dale P Sandler; Minouk J Schoemaker; Patrick M Sluss; Malin Sund; Anthony J Swerdlow; Kala Visvanathan; Mengling Liu; Anne Zeleniuch-Jacquotte

doi:10.1210/clinem/dgab461

Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Tess V Clendenen, Wenzhen Ge, Karen L Koenig, Yelena Afanasyeva, Claudia Agnoli, Elizabeth Bertone-Johnson, Louise A Brinton, Farbod Darvishian, Joanne F Dorgan, A Heather Eliassen, Roni T Falk, Göran Hallmans, Susan E Hankinson, Judith Hoffman-Bolton, Timothy J Key, Vittorio Krogh, Hazel B Nichols, Dale P Sandler, Minouk J Schoemaker, Patrick M SlussMalin Sund, Anthony J Swerdlow, Kala Visvanathan, Mengling Liu, Anne Zeleniuch-Jacquotte

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

CONTEXT: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.

OBJECTIVE: This study assessed whether risk factors for breast cancer are correlates of AMH concentration.

METHODS: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population.

RESULTS: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05).

CONCLUSION: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.

Original language	English
Pages (from-to)	e4542-e4553
Journal	The Journal of clinical endocrinology and metabolism
Volume	106
Issue number	11
DOIs	https://doi.org/10.1210/clinem/dgab461
Publication status	Published - Oct 21 2021

Keywords

Adult
Aging/blood
Anti-Mullerian Hormone/blood
Biomarkers
Body Mass Index
Breast Diseases/blood
Breast Neoplasms/blood
Cohort Studies
Cross-Sectional Studies
Female
Humans
Middle Aged
Ovarian Reserve
Pregnancy
Premenopause/blood
Risk Factors

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10.1210/clinem/dgab461

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Clendenen, T. V., Ge, W., Koenig, K. L., Afanasyeva, Y., Agnoli, C., Bertone-Johnson, E., Brinton, L. A., Darvishian, F., Dorgan, J. F., Eliassen, A. H., Falk, R. T., Hallmans, G., Hankinson, S. E., Hoffman-Bolton, J., Key, T. J., Krogh, V., Nichols, H. B., Sandler, D. P., Schoemaker, M. J., ... Zeleniuch-Jacquotte, A. (2021). Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women. The Journal of clinical endocrinology and metabolism, 106(11), e4542-e4553. https://doi.org/10.1210/clinem/dgab461

Clendenen, TV, Ge, W, Koenig, KL, Afanasyeva, Y, Agnoli, C, Bertone-Johnson, E, Brinton, LA, Darvishian, F, Dorgan, JF, Eliassen, AH, Falk, RT, Hallmans, G, Hankinson, SE, Hoffman-Bolton, J, Key, TJ, Krogh, V, Nichols, HB, Sandler, DP, Schoemaker, MJ, Sluss, PM, Sund, M, Swerdlow, AJ, Visvanathan, K, Liu, M & Zeleniuch-Jacquotte, A 2021, 'Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women', The Journal of clinical endocrinology and metabolism, vol. 106, no. 11, pp. e4542-e4553. https://doi.org/10.1210/clinem/dgab461

@article{efb521a9f77b4fb993a5e224a139d668,

title = "Breast Cancer Risk Factors and Circulating Anti-M{\"u}llerian Hormone Concentration in Healthy Premenopausal Women",

abstract = "CONTEXT: We previously reported that anti-M{\"u}llerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.OBJECTIVE: This study assessed whether risk factors for breast cancer are correlates of AMH concentration.METHODS: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population.RESULTS: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05).CONCLUSION: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.",

keywords = "Adult, Aging/blood, Anti-Mullerian Hormone/blood, Biomarkers, Body Mass Index, Breast Diseases/blood, Breast Neoplasms/blood, Cohort Studies, Cross-Sectional Studies, Female, Humans, Middle Aged, Ovarian Reserve, Pregnancy, Premenopause/blood, Risk Factors",

author = "Clendenen, {Tess V} and Wenzhen Ge and Koenig, {Karen L} and Yelena Afanasyeva and Claudia Agnoli and Elizabeth Bertone-Johnson and Brinton, {Louise A} and Farbod Darvishian and Dorgan, {Joanne F} and Eliassen, {A Heather} and Falk, {Roni T} and G{\"o}ran Hallmans and Hankinson, {Susan E} and Judith Hoffman-Bolton and Key, {Timothy J} and Vittorio Krogh and Nichols, {Hazel B} and Sandler, {Dale P} and Schoemaker, {Minouk J} and Sluss, {Patrick M} and Malin Sund and Swerdlow, {Anthony J} and Kala Visvanathan and Mengling Liu and Anne Zeleniuch-Jacquotte",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

year = "2021",

month = oct,

day = "21",

doi = "10.1210/clinem/dgab461",

language = "English",

volume = "106",

pages = "e4542--e4553",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "The Endocrine Society",

number = "11",

}

TY - JOUR

T1 - Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

AU - Clendenen, Tess V

AU - Ge, Wenzhen

AU - Koenig, Karen L

AU - Afanasyeva, Yelena

AU - Agnoli, Claudia

AU - Bertone-Johnson, Elizabeth

AU - Brinton, Louise A

AU - Darvishian, Farbod

AU - Dorgan, Joanne F

AU - Eliassen, A Heather

AU - Falk, Roni T

AU - Hallmans, Göran

AU - Hankinson, Susan E

AU - Hoffman-Bolton, Judith

AU - Key, Timothy J

AU - Krogh, Vittorio

AU - Nichols, Hazel B

AU - Sandler, Dale P

AU - Schoemaker, Minouk J

AU - Sluss, Patrick M

AU - Sund, Malin

AU - Swerdlow, Anthony J

AU - Visvanathan, Kala

AU - Liu, Mengling

AU - Zeleniuch-Jacquotte, Anne

PY - 2021/10/21

Y1 - 2021/10/21

N2 - CONTEXT: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.OBJECTIVE: This study assessed whether risk factors for breast cancer are correlates of AMH concentration.METHODS: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population.RESULTS: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05).CONCLUSION: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.

AB - CONTEXT: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.OBJECTIVE: This study assessed whether risk factors for breast cancer are correlates of AMH concentration.METHODS: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population.RESULTS: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05).CONCLUSION: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.

KW - Adult

KW - Aging/blood

KW - Anti-Mullerian Hormone/blood

KW - Biomarkers

KW - Body Mass Index

KW - Breast Diseases/blood

KW - Breast Neoplasms/blood

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Middle Aged

KW - Ovarian Reserve

KW - Pregnancy

KW - Premenopause/blood

KW - Risk Factors

U2 - 10.1210/clinem/dgab461

DO - 10.1210/clinem/dgab461

M3 - Article

C2 - 34157104

SN - 0021-972X

VL - 106

SP - e4542-e4553

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 11

ER -

Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women

Abstract

Keywords

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