Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies

E. E. Calle; C. W. Heath; H. L. Miracle-McMahill; R. J. Coates; J. M. Liff; S. Franceschi; R. Talamini; N. Chantarakul; S. Koetsawang; D. RachawatRachawat; A. Morabia; L. Schuman; W. Stewart; M. Szklo; C. Bain; F. Schofield; V. Siskind; P. Band; A. J. Coldman; R. P. Gallagher; T. G. Hislop; P. Yang; S. W. Duffy; L. M. Kolonel; A. M Y Nomura; M. W. Oberle; H. W. Ory; H. B. Peterson; H. G. Wilson; P. A. Wingo; K. Ebeling; D. Kunde; P. Nishan; G. Colditz; N. Martin; T. Pardthaisong; S. Silpisornkosol; C. Theetranont; B. Boosiri; S. Chutivongse; P. Jimakorn; P. Virutamasen; C. Wongsrichanalai; A. J. McMichael; T. Rohan; M. Ewertz; C. Paul; D. C G Skegg; P. Boyle; M. Evstifeeva; J. R. Daling; K. Malone; E. A. Noonan; J. L. Stanford; D. B. Thomas; N. S. Weiss; E. White; N. Andrieu; A. Brêmond; F. Clavel; B. Gairard; J. Lansac; L. Piana; R. Renaud; S. R P Fine; H. R. Cuevas; P. Ontiveros; A. Palet; S. B. Salazar; N. Aristizabel; A. Cuadros; A. Bachelot; M. G. Lê; J. Deacon; J. Peto; C. N. Taylor; E. Alfandary; B. Modan; E. Ron; G. D. Friedman; R. A. Hiatt; T. Bishop; J. Kosmelj; M. Primic-Zakelj; B. Ravnihar; J. Stare; W. L. Beeson; G. Fraser; D. S. Allen; R. D. Bulbrook; J. Cuzick; I. S. Fentiman; J. L. Hayward; D. Y. Wang; R. L. Hanson; M. C. Leske; M. C. Mahoney; P. C. Nasca; A. O. Varma; A. L. Weinstein; T. R. Moller; H. Olsson; J. Ranstam; R. A. Goldbohm; P. A. van den Brandt; R. A. Apelo; J. Baens; J. R. de la Cruz; B. Javier; L. B. Lacaya; C. A. Ngelangel; C. La Vecchia; E. Negri; E. Marubini; M. Ferraroni; M. Gerber; S. Richardson; C. Segala; D. Gatei; P. Kenya; A. Kungu; J. G. Mati; L. A. Brinton; R. Hoover; C. Schairer; R. Spirtas; H. P. Lee; M. A. Rookus; F. V. van Leeuwen; J. A. Schoenberg; M. D. Gammon; E. A. Clarke; L. Jones; K. McPherson; A. Neil; M. Vessey; D. Yeates; V. Beral; D. Bull; B. Crossley; C. Hermon; S. Jones; T. Key; C. Lewis; G. Reeves; P. Smith; R. Collins; R. Doll; R. Peto; P. Hannaford; C. Kay; L. Rosero-Bixby; Y. T. Gao; J. M. Yuan; H. Y. Wei; T. Yun; C. Zhiheng; G. Berry; J. Cooper Booth; T. Jelihovsky; R. MacLennan; R. Shearman; Q. S. Wang; C. J. Baines; A. B. Miller; C. Wall; E. Lund; H. Stalsberg; A. Dabancens; L. Martinez; R. Molina; O. Salas; F. E. Alexander; B. S. Hulka; C. E D Chilvers; L. Bernstein; R. W. Haile; A. Paganini-Hill; M. C. Pike; R. K. Ross; G. Ursin; M. C. Yu; H. O. Adami; R. Bergstrom; M. P. Longnecker; P. Newcomb; T. M N Farley; S. Holck; O. Meirik

Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies

E. E. Calle, C. W. Heath, H. L. Miracle-McMahill, R. J. Coates, J. M. Liff, S. Franceschi, R. Talamini, N. Chantarakul, S. Koetsawang, D. RachawatRachawat, A. Morabia, L. Schuman, W. Stewart, M. Szklo, C. Bain, F. Schofield, V. Siskind, P. Band, A. J. Coldman, R. P. GallagherT. G. Hislop, P. Yang, S. W. Duffy, L. M. Kolonel, A. M Y Nomura, M. W. Oberle, H. W. Ory, H. B. Peterson, H. G. Wilson, P. A. Wingo, K. Ebeling, D. Kunde, P. Nishan, G. Colditz, N. Martin, T. Pardthaisong, S. Silpisornkosol, C. Theetranont, B. Boosiri, S. Chutivongse, P. Jimakorn, P. Virutamasen, C. Wongsrichanalai, A. J. McMichael, T. Rohan, M. Ewertz, C. Paul, D. C G Skegg, P. Boyle, M. Evstifeeva, J. R. Daling, K. Malone, E. A. Noonan, J. L. Stanford, D. B. Thomas, N. S. Weiss, E. White, N. Andrieu, A. Brêmond, F. Clavel, B. Gairard, J. Lansac, L. Piana, R. Renaud, S. R P Fine, H. R. Cuevas, P. Ontiveros, A. Palet, S. B. Salazar, N. Aristizabel, A. Cuadros, A. Bachelot, M. G. Lê, J. Deacon, J. Peto, C. N. Taylor, E. Alfandary, B. Modan, E. Ron, G. D. Friedman, R. A. Hiatt, T. Bishop, J. Kosmelj, M. Primic-Zakelj, B. Ravnihar, J. Stare, W. L. Beeson, G. Fraser, D. S. Allen, R. D. Bulbrook, J. Cuzick, I. S. Fentiman, J. L. Hayward, D. Y. Wang, R. L. Hanson, M. C. Leske, M. C. Mahoney, P. C. Nasca, A. O. Varma, A. L. Weinstein, T. R. Moller, H. Olsson, J. Ranstam, R. A. Goldbohm, P. A. van den Brandt, R. A. Apelo, J. Baens, J. R. de la Cruz, B. Javier, L. B. Lacaya, C. A. Ngelangel, C. La Vecchia, E. Negri, E. Marubini, M. Ferraroni, M. Gerber, S. Richardson, C. Segala, D. Gatei, P. Kenya, A. Kungu, J. G. Mati, L. A. Brinton, R. Hoover, C. Schairer, R. Spirtas, H. P. Lee, M. A. Rookus, F. V. van Leeuwen, J. A. Schoenberg, M. D. Gammon, E. A. Clarke, L. Jones, K. McPherson, A. Neil, M. Vessey, D. Yeates, V. Beral, D. Bull, B. Crossley, C. Hermon, S. Jones, T. Key, C. Lewis, G. Reeves, P. Smith, R. Collins, R. Doll, R. Peto, P. Hannaford, C. Kay, L. Rosero-Bixby, Y. T. Gao, J. M. Yuan, H. Y. Wei, T. Yun, C. Zhiheng, G. Berry, J. Cooper Booth, T. Jelihovsky, R. MacLennan, R. Shearman, Q. S. Wang, C. J. Baines, A. B. Miller, C. Wall, E. Lund, H. Stalsberg, A. Dabancens, L. Martinez, R. Molina, O. Salas, F. E. Alexander, B. S. Hulka, C. E D Chilvers, L. Bernstein, R. W. Haile, A. Paganini-Hill, M. C. Pike, R. K. Ross, G. Ursin, M. C. Yu, H. O. Adami, R. Bergstrom, M. P. Longnecker, P. Newcomb, T. M N Farley, S. Holck, O. Meirik

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed the worldwide epidemiological evidence on the relation between breast cancer risk and use of hormonal contraceptives. Methods: Individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 studies conducted in 25 countries were collected, checked, and analysed centrally. Estimates of the relative risk for breast cancer were obtained by a modification of the Mantel-Haenszel method. All analyses were stratified by study, age at diagnosis, parity, and, where appropriate, the age a woman was when her first child was born, and the age she was when her risk of conception ceased. Findings: The results provide strong evidence for two main conclusions. First, while women are taking combined oral contraceptives and in the 10 years after stopping there is a small increase in the relative risk of having breast cancer diagnosed (relative risk [95% Cl] in current users 1·24 [1·15-1·33], 2p

Original language	English
Pages (from-to)	1713-1727
Number of pages	15
Journal	Lancet
Volume	347
Issue number	9017
Publication status	Published - Jun 22 1996

ASJC Scopus subject areas

Medicine(all)

Cite this

Calle, E. E., Heath, C. W., Miracle-McMahill, H. L., Coates, R. J., Liff, J. M., Franceschi, S., Talamini, R., Chantarakul, N., Koetsawang, S., RachawatRachawat, D., Morabia, A., Schuman, L., Stewart, W., Szklo, M., Bain, C., Schofield, F., Siskind, V., Band, P., Coldman, A. J., ... Meirik, O. (1996). Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet, 347(9017), 1713-1727.

Breast cancer and hormonal contraceptives : Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. / Calle, E. E.; Heath, C. W.; Miracle-McMahill, H. L. et al.

In: Lancet, Vol. 347, No. 9017, 22.06.1996, p. 1713-1727.

Research output: Contribution to journal › Article › peer-review

Calle, EE, Heath, CW, Miracle-McMahill, HL, Coates, RJ, Liff, JM, Franceschi, S, Talamini, R, Chantarakul, N, Koetsawang, S, RachawatRachawat, D, Morabia, A, Schuman, L, Stewart, W, Szklo, M, Bain, C, Schofield, F, Siskind, V, Band, P, Coldman, AJ, Gallagher, RP, Hislop, TG, Yang, P, Duffy, SW, Kolonel, LM, Nomura, AMY, Oberle, MW, Ory, HW, Peterson, HB, Wilson, HG, Wingo, PA, Ebeling, K, Kunde, D, Nishan, P, Colditz, G, Martin, N, Pardthaisong, T, Silpisornkosol, S, Theetranont, C, Boosiri, B, Chutivongse, S, Jimakorn, P, Virutamasen, P, Wongsrichanalai, C, McMichael, AJ, Rohan, T, Ewertz, M, Paul, C, Skegg, DCG, Boyle, P, Evstifeeva, M, Daling, JR, Malone, K, Noonan, EA, Stanford, JL, Thomas, DB, Weiss, NS, White, E, Andrieu, N, Brêmond, A, Clavel, F, Gairard, B, Lansac, J, Piana, L, Renaud, R, Fine, SRP, Cuevas, HR, Ontiveros, P, Palet, A, Salazar, SB, Aristizabel, N, Cuadros, A, Bachelot, A, Lê, MG, Deacon, J, Peto, J, Taylor, CN, Alfandary, E, Modan, B, Ron, E, Friedman, GD, Hiatt, RA, Bishop, T, Kosmelj, J, Primic-Zakelj, M, Ravnihar, B, Stare, J, Beeson, WL, Fraser, G, Allen, DS, Bulbrook, RD, Cuzick, J, Fentiman, IS, Hayward, JL, Wang, DY, Hanson, RL, Leske, MC, Mahoney, MC, Nasca, PC, Varma, AO, Weinstein, AL, Moller, TR, Olsson, H, Ranstam, J, Goldbohm, RA, van den Brandt, PA, Apelo, RA, Baens, J, de la Cruz, JR, Javier, B, Lacaya, LB, Ngelangel, CA, La Vecchia, C, Negri, E, Marubini, E, Ferraroni, M, Gerber, M, Richardson, S, Segala, C, Gatei, D, Kenya, P, Kungu, A, Mati, JG, Brinton, LA, Hoover, R, Schairer, C, Spirtas, R, Lee, HP, Rookus, MA, van Leeuwen, FV, Schoenberg, JA, Gammon, MD, Clarke, EA, Jones, L, McPherson, K, Neil, A, Vessey, M, Yeates, D, Beral, V, Bull, D, Crossley, B, Hermon, C, Jones, S, Key, T, Lewis, C, Reeves, G, Smith, P, Collins, R, Doll, R, Peto, R, Hannaford, P, Kay, C, Rosero-Bixby, L, Gao, YT, Yuan, JM, Wei, HY, Yun, T, Zhiheng, C, Berry, G, Cooper Booth, J, Jelihovsky, T, MacLennan, R, Shearman, R, Wang, QS, Baines, CJ, Miller, AB, Wall, C, Lund, E, Stalsberg, H, Dabancens, A, Martinez, L, Molina, R, Salas, O, Alexander, FE, Hulka, BS, Chilvers, CED, Bernstein, L, Haile, RW, Paganini-Hill, A, Pike, MC, Ross, RK, Ursin, G, Yu, MC, Adami, HO, Bergstrom, R, Longnecker, MP, Newcomb, P, Farley, TMN, Holck, S & Meirik, O 1996, 'Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies', Lancet, vol. 347, no. 9017, pp. 1713-1727.

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title = "Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies",

abstract = "Background: The Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed the worldwide epidemiological evidence on the relation between breast cancer risk and use of hormonal contraceptives. Methods: Individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 studies conducted in 25 countries were collected, checked, and analysed centrally. Estimates of the relative risk for breast cancer were obtained by a modification of the Mantel-Haenszel method. All analyses were stratified by study, age at diagnosis, parity, and, where appropriate, the age a woman was when her first child was born, and the age she was when her risk of conception ceased. Findings: The results provide strong evidence for two main conclusions. First, while women are taking combined oral contraceptives and in the 10 years after stopping there is a small increase in the relative risk of having breast cancer diagnosed (relative risk [95% Cl] in current users 1·24 [1·15-1·33], 2p",

author = "Calle, {E. E.} and Heath, {C. W.} and Miracle-McMahill, {H. L.} and Coates, {R. J.} and Liff, {J. M.} and S. Franceschi and R. Talamini and N. Chantarakul and S. Koetsawang and D. RachawatRachawat and A. Morabia and L. Schuman and W. Stewart and M. Szklo and C. Bain and F. Schofield and V. Siskind and P. Band and Coldman, {A. J.} and Gallagher, {R. P.} and Hislop, {T. G.} and P. Yang and Duffy, {S. W.} and Kolonel, {L. M.} and Nomura, {A. M Y} and Oberle, {M. W.} and Ory, {H. W.} and Peterson, {H. B.} and Wilson, {H. G.} and Wingo, {P. A.} and K. Ebeling and D. Kunde and P. Nishan and G. Colditz and N. Martin and T. Pardthaisong and S. Silpisornkosol and C. Theetranont and B. Boosiri and S. Chutivongse and P. Jimakorn and P. Virutamasen and C. Wongsrichanalai and McMichael, {A. J.} and T. Rohan and M. Ewertz and C. Paul and Skegg, {D. C G} and P. Boyle and M. Evstifeeva and Daling, {J. R.} and K. Malone and Noonan, {E. A.} and Stanford, {J. L.} and Thomas, {D. B.} and Weiss, {N. S.} and E. White and N. Andrieu and A. Br{\^e}mond and F. Clavel and B. Gairard and J. Lansac and L. Piana and R. Renaud and Fine, {S. R P} and Cuevas, {H. R.} and P. Ontiveros and A. Palet and Salazar, {S. B.} and N. Aristizabel and A. Cuadros and A. Bachelot and L{\^e}, {M. G.} and J. Deacon and J. Peto and Taylor, {C. N.} and E. Alfandary and B. Modan and E. Ron and Friedman, {G. D.} and Hiatt, {R. A.} and T. Bishop and J. Kosmelj and M. Primic-Zakelj and B. Ravnihar and J. Stare and Beeson, {W. L.} and G. Fraser and Allen, {D. S.} and Bulbrook, {R. D.} and J. Cuzick and Fentiman, {I. S.} and Hayward, {J. L.} and Wang, {D. Y.} and Hanson, {R. L.} and Leske, {M. C.} and Mahoney, {M. C.} and Nasca, {P. C.} and Varma, {A. O.} and Weinstein, {A. L.} and Moller, {T. R.} and H. Olsson and J. Ranstam and Goldbohm, {R. A.} and {van den Brandt}, {P. A.} and Apelo, {R. A.} and J. Baens and {de la Cruz}, {J. R.} and B. Javier and Lacaya, {L. B.} and Ngelangel, {C. A.} and {La Vecchia}, C. and E. Negri and E. Marubini and M. Ferraroni and M. Gerber and S. Richardson and C. Segala and D. Gatei and P. Kenya and A. Kungu and Mati, {J. G.} and Brinton, {L. A.} and R. Hoover and C. Schairer and R. Spirtas and Lee, {H. P.} and Rookus, {M. A.} and {van Leeuwen}, {F. V.} and Schoenberg, {J. A.} and Gammon, {M. D.} and Clarke, {E. A.} and L. Jones and K. McPherson and A. Neil and M. Vessey and D. Yeates and V. Beral and D. Bull and B. Crossley and C. Hermon and S. Jones and T. Key and C. Lewis and G. Reeves and P. Smith and R. Collins and R. Doll and R. Peto and P. Hannaford and C. Kay and L. Rosero-Bixby and Gao, {Y. T.} and Yuan, {J. M.} and Wei, {H. Y.} and T. Yun and C. Zhiheng and G. Berry and {Cooper Booth}, J. and T. Jelihovsky and R. MacLennan and R. Shearman and Wang, {Q. S.} and Baines, {C. J.} and Miller, {A. B.} and C. Wall and E. Lund and H. Stalsberg and A. Dabancens and L. Martinez and R. Molina and O. Salas and Alexander, {F. E.} and Hulka, {B. S.} and Chilvers, {C. E D} and L. Bernstein and Haile, {R. W.} and A. Paganini-Hill and Pike, {M. C.} and Ross, {R. K.} and G. Ursin and Yu, {M. C.} and Adami, {H. O.} and R. Bergstrom and Longnecker, {M. P.} and P. Newcomb and Farley, {T. M N} and S. Holck and O. Meirik",

year = "1996",

month = jun,

day = "22",

language = "English",

volume = "347",

pages = "1713--1727",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Lancet Publishing Group",

number = "9017",

}

TY - JOUR

T1 - Breast cancer and hormonal contraceptives

T2 - Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies

AU - Calle, E. E.

AU - Heath, C. W.

AU - Miracle-McMahill, H. L.

AU - Coates, R. J.

AU - Liff, J. M.

AU - Franceschi, S.

AU - Talamini, R.

AU - Chantarakul, N.

AU - Koetsawang, S.

AU - RachawatRachawat, D.

AU - Morabia, A.

AU - Schuman, L.

AU - Stewart, W.

AU - Szklo, M.

AU - Bain, C.

AU - Schofield, F.

AU - Siskind, V.

AU - Band, P.

AU - Coldman, A. J.

AU - Gallagher, R. P.

AU - Hislop, T. G.

AU - Yang, P.

AU - Duffy, S. W.

AU - Kolonel, L. M.

AU - Nomura, A. M Y

AU - Oberle, M. W.

AU - Ory, H. W.

AU - Peterson, H. B.

AU - Wilson, H. G.

AU - Wingo, P. A.

AU - Ebeling, K.

AU - Kunde, D.

AU - Nishan, P.

AU - Colditz, G.

AU - Martin, N.

AU - Pardthaisong, T.

AU - Silpisornkosol, S.

AU - Theetranont, C.

AU - Boosiri, B.

AU - Chutivongse, S.

AU - Jimakorn, P.

AU - Virutamasen, P.

AU - Wongsrichanalai, C.

AU - McMichael, A. J.

AU - Rohan, T.

AU - Ewertz, M.

AU - Paul, C.

AU - Skegg, D. C G

AU - Boyle, P.

AU - Evstifeeva, M.

AU - Daling, J. R.

AU - Malone, K.

AU - Noonan, E. A.

AU - Stanford, J. L.

AU - Thomas, D. B.

AU - Weiss, N. S.

AU - White, E.

AU - Andrieu, N.

AU - Brêmond, A.

AU - Clavel, F.

AU - Gairard, B.

AU - Lansac, J.

AU - Piana, L.

AU - Renaud, R.

AU - Fine, S. R P

AU - Cuevas, H. R.

AU - Ontiveros, P.

AU - Palet, A.

AU - Salazar, S. B.

AU - Aristizabel, N.

AU - Cuadros, A.

AU - Bachelot, A.

AU - Lê, M. G.

AU - Deacon, J.

AU - Peto, J.

AU - Taylor, C. N.

AU - Alfandary, E.

AU - Modan, B.

AU - Ron, E.

AU - Friedman, G. D.

AU - Hiatt, R. A.

AU - Bishop, T.

AU - Kosmelj, J.

AU - Primic-Zakelj, M.

AU - Ravnihar, B.

AU - Stare, J.

AU - Beeson, W. L.

AU - Fraser, G.

AU - Allen, D. S.

AU - Bulbrook, R. D.

AU - Cuzick, J.

AU - Fentiman, I. S.

AU - Hayward, J. L.

AU - Wang, D. Y.

AU - Hanson, R. L.

AU - Leske, M. C.

AU - Mahoney, M. C.

AU - Nasca, P. C.

AU - Varma, A. O.

AU - Weinstein, A. L.

AU - Moller, T. R.

AU - Olsson, H.

AU - Ranstam, J.

AU - Goldbohm, R. A.

AU - van den Brandt, P. A.

AU - Apelo, R. A.

AU - Baens, J.

AU - de la Cruz, J. R.

AU - Javier, B.

AU - Lacaya, L. B.

AU - Ngelangel, C. A.

AU - La Vecchia, C.

AU - Negri, E.

AU - Marubini, E.

AU - Ferraroni, M.

AU - Gerber, M.

AU - Richardson, S.

AU - Segala, C.

AU - Gatei, D.

AU - Kenya, P.

AU - Kungu, A.

AU - Mati, J. G.

AU - Brinton, L. A.

AU - Hoover, R.

AU - Schairer, C.

AU - Spirtas, R.

AU - Lee, H. P.

AU - Rookus, M. A.

AU - van Leeuwen, F. V.

AU - Schoenberg, J. A.

AU - Gammon, M. D.

AU - Clarke, E. A.

AU - Jones, L.

AU - McPherson, K.

AU - Neil, A.

AU - Vessey, M.

AU - Yeates, D.

AU - Beral, V.

AU - Bull, D.

AU - Crossley, B.

AU - Hermon, C.

AU - Jones, S.

AU - Key, T.

AU - Lewis, C.

AU - Reeves, G.

AU - Smith, P.

AU - Collins, R.

AU - Doll, R.

AU - Peto, R.

AU - Hannaford, P.

AU - Kay, C.

AU - Rosero-Bixby, L.

AU - Gao, Y. T.

AU - Yuan, J. M.

AU - Wei, H. Y.

AU - Yun, T.

AU - Zhiheng, C.

AU - Berry, G.

AU - Cooper Booth, J.

AU - Jelihovsky, T.

AU - MacLennan, R.

AU - Shearman, R.

AU - Wang, Q. S.

AU - Baines, C. J.

AU - Miller, A. B.

AU - Wall, C.

AU - Lund, E.

AU - Stalsberg, H.

AU - Dabancens, A.

AU - Martinez, L.

AU - Molina, R.

AU - Salas, O.

AU - Alexander, F. E.

AU - Hulka, B. S.

AU - Chilvers, C. E D

AU - Bernstein, L.

AU - Haile, R. W.

AU - Paganini-Hill, A.

AU - Pike, M. C.

AU - Ross, R. K.

AU - Ursin, G.

AU - Yu, M. C.

AU - Adami, H. O.

AU - Bergstrom, R.

AU - Longnecker, M. P.

AU - Newcomb, P.

AU - Farley, T. M N

AU - Holck, S.

AU - Meirik, O.

PY - 1996/6/22

Y1 - 1996/6/22

N2 - Background: The Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed the worldwide epidemiological evidence on the relation between breast cancer risk and use of hormonal contraceptives. Methods: Individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 studies conducted in 25 countries were collected, checked, and analysed centrally. Estimates of the relative risk for breast cancer were obtained by a modification of the Mantel-Haenszel method. All analyses were stratified by study, age at diagnosis, parity, and, where appropriate, the age a woman was when her first child was born, and the age she was when her risk of conception ceased. Findings: The results provide strong evidence for two main conclusions. First, while women are taking combined oral contraceptives and in the 10 years after stopping there is a small increase in the relative risk of having breast cancer diagnosed (relative risk [95% Cl] in current users 1·24 [1·15-1·33], 2p

AB - Background: The Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed the worldwide epidemiological evidence on the relation between breast cancer risk and use of hormonal contraceptives. Methods: Individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 studies conducted in 25 countries were collected, checked, and analysed centrally. Estimates of the relative risk for breast cancer were obtained by a modification of the Mantel-Haenszel method. All analyses were stratified by study, age at diagnosis, parity, and, where appropriate, the age a woman was when her first child was born, and the age she was when her risk of conception ceased. Findings: The results provide strong evidence for two main conclusions. First, while women are taking combined oral contraceptives and in the 10 years after stopping there is a small increase in the relative risk of having breast cancer diagnosed (relative risk [95% Cl] in current users 1·24 [1·15-1·33], 2p

UR - http://www.scopus.com/inward/record.url?scp=0242390079&partnerID=8YFLogxK

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M3 - Article

C2 - 8656904

AN - SCOPUS:0242390079

SN - 0140-6736

VL - 347

SP - 1713

EP - 1727

JO - The Lancet

JF - The Lancet

IS - 9017

ER -

Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies

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