Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

Sebastiano Mercadante; Arturo Cuomo; Augusto Caraceni; Rocco D. Mediati; Massimo Mammucari; Silvia Natoli; Marzia Lazzari; Mario Dauri; M. Airoldi; Giuseppe Azzarello; Mauro Bandera; Livio Blasi; Giacomo Cartenì; B. Chiurazzi; Benedetta Veruska Pierpaola Costanzo; D. Degiovanni; Flavio Fusco; Vittorio Guardamagna; Rosario Vincenzo Iaffaioli; S. Liguori; Vito Lorusso; Sergio Mameli; Rodolfo Mattioli; Teresita Mazzei; Rita M. Melotti; Valentino Menardo; Danilo Miotti; Stefano Moroso; Stefano de Santis; R. Orsetti; Alfonso Papa; Sergio Ricci; Alessandro F. Sabato; E. Scelzi; Michele Sofia; Giuseppe Tonini; Federica Aielli; Alessandro Valle; Silvia Angelini; Daniela Iacono; Federica Mazzuca; Alessia Carnevale; Paolo Bonome; Luca Nicosia; Claudia Scaringi; Adelaide Montalto; G. Russo; Cira Antonietta Forte; Gennaro Esposito; Paola Bracchi; Ernesto Zecca; Tiziana Campa; Silvia Grecchi; Alessandra Pigni; Annunziata Sammaro; Lucia Dodaro; Giovanna Ballerini; Renato Vellucci; Clarissa Caldarulo; E. Palombo; Marco Diviza; Valentina Gianfelice; Claudia Silvestri; Simona Finocchi; Viviana Contu; Gianluca Fora; Fulvia Pedani; Massimiliano Icardi; Elisa Bellini; Alfredo Celano; Roberto Berardo; Oliviero Ostellino; Kayta Sartori; Paola Demartini; Raffaella Scroccaro; Giorgia Boscolo; Donata Sartori; Francesco Rosetti; G. Artioli; L. Borgato; Giovanni Bertoldero; Barbara Veronese; Ilaria Vallini; Alessandro Tuzi; Elena Bolzacchini; G. Pinotti; Massimiliano Alù; A. Usset; Carmela Arcuri; Agata Laudani; Alessio Pepe; Sarah Scagliarini; Massimiliano Savio Maria Sgarlata; Massimo Raimondi; Salvatore Maria Giovanni Valenti; Alberto Bucceri; Alma Kasa; Paola Budel; Anna Caramellino; Paola Ballarino; E. Donelli; Stefania Silvestro; Rossella Tonetti; S. Bozzoni; Angela Cocquio; Carmela Romano; Anna Nappi; Chiara De Divitiis; Silvia Ghidoni; Rosalba Cortinovis; Roberta Marchesi; Michele Fortis; Loredana Palermo; Giovanni Maria Pisanu; Maura Carboni; Francesca Meloni; Daniele Barillari; Luca Imperatori; Gianni Grilli; G. Laici; Sara Diacciati; P. Petreni; Boaz Samolsky Dekel; Federica Marsigli; Miriam Manfreda; Silvia Ghedini; Emanuela Bruno; Emanuele Salvini; Davide Gerboni; Serena Saulle; Roberta Carella; Gaetano Pascoletti; Silvia Bolzonello; Marta Bonotto; Silvia Ellero; Gianpiero Fasola; Elena Ongaro; Cristina Borghesi; Lucia Germani; Edoardo de Ruvo; Federica Marchetti; Milena Pasquale; Lucia Masu; Dario Tammaro; Elisabetta Saracco; Maria Teresa Di Dato; Maurizio Ferrara; Andrea Pironti; Pietro Buonavolontà; Laura Ginocchi; Gianna Musettini; Andrea Antonuzzo; C. Caparello; Maurizio Lucchesi; Azzurra Farnesi; Mari Zampieri; Manuela Pisciotta; Iacopo Fioroni; Raffaele Ratta; Maria Concetta Cursano; Daniele Santini; Cinzia Potestà; Gloria Gallo; Benhaz Saber

doi:10.1007/s12325-016-0440-4

Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

Sebastiano Mercadante, Arturo Cuomo, Augusto Caraceni, Rocco D. Mediati, Massimo Mammucari, Silvia Natoli, Marzia Lazzari, Mario Dauri, M. Airoldi, Giuseppe Azzarello, Mauro Bandera, Livio Blasi, Giacomo Cartenì, B. Chiurazzi, Benedetta Veruska Pierpaola Costanzo, D. Degiovanni, Flavio Fusco, Vittorio Guardamagna, Rosario Vincenzo Iaffaioli, S. LiguoriVito Lorusso, Sergio Mameli, Rodolfo Mattioli, Teresita Mazzei, Rita M. Melotti, Valentino Menardo, Danilo Miotti, Stefano Moroso, Stefano de Santis, R. Orsetti, Alfonso Papa, Sergio Ricci, Alessandro F. Sabato, E. Scelzi, Michele Sofia, Giuseppe Tonini, Federica Aielli, Alessandro Valle, Silvia Angelini, Daniela Iacono, Federica Mazzuca, Alessia Carnevale, Paolo Bonome, Luca Nicosia, Claudia Scaringi, Adelaide Montalto, G. Russo, Cira Antonietta Forte, Gennaro Esposito, Paola Bracchi, Ernesto Zecca, Tiziana Campa, Silvia Grecchi, Alessandra Pigni, Annunziata Sammaro, Lucia Dodaro, Giovanna Ballerini, Renato Vellucci, Clarissa Caldarulo, E. Palombo, Marco Diviza, Valentina Gianfelice, Claudia Silvestri, Simona Finocchi, Viviana Contu, Gianluca Fora, Fulvia Pedani, Massimiliano Icardi, Elisa Bellini, Alfredo Celano, Roberto Berardo, Oliviero Ostellino, Kayta Sartori, Paola Demartini, Raffaella Scroccaro, Giorgia Boscolo, Donata Sartori, Francesco Rosetti, G. Artioli, L. Borgato, Giovanni Bertoldero, Barbara Veronese, Ilaria Vallini, Alessandro Tuzi, Elena Bolzacchini, G. Pinotti, Massimiliano Alù, A. Usset, Carmela Arcuri, Agata Laudani, Alessio Pepe, Sarah Scagliarini, Massimiliano Savio Maria Sgarlata, Massimo Raimondi, Salvatore Maria Giovanni Valenti, Alberto Bucceri, Alma Kasa, Paola Budel, Anna Caramellino, Paola Ballarino, E. Donelli, Stefania Silvestro, Rossella Tonetti, S. Bozzoni, Angela Cocquio, Carmela Romano, Anna Nappi, Chiara De Divitiis, Silvia Ghidoni, Rosalba Cortinovis, Roberta Marchesi, Michele Fortis, Loredana Palermo, Giovanni Maria Pisanu, Maura Carboni, Francesca Meloni, Daniele Barillari, Luca Imperatori, Gianni Grilli, G. Laici, Sara Diacciati, P. Petreni, Boaz Samolsky Dekel, Federica Marsigli, Miriam Manfreda, Silvia Ghedini, Emanuela Bruno, Emanuele Salvini, Davide Gerboni, Serena Saulle, Roberta Carella, Gaetano Pascoletti, Silvia Bolzonello, Marta Bonotto, Silvia Ellero, Gianpiero Fasola, Elena Ongaro, Cristina Borghesi, Lucia Germani, Edoardo de Ruvo, Federica Marchetti, Milena Pasquale, Lucia Masu, Dario Tammaro, Elisabetta Saracco, Maria Teresa Di Dato, Maurizio Ferrara, Andrea Pironti, Pietro Buonavolontà, Laura Ginocchi, Gianna Musettini, Andrea Antonuzzo, C. Caparello, Maurizio Lucchesi, Azzurra Farnesi, Mari Zampieri, Manuela Pisciotta, Iacopo Fioroni, Raffaele Ratta, Maria Concetta Cursano, Daniele Santini, Cinzia Potestà, Gloria Gallo, Benhaz Saber

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here. Methods: Thirty-two clinical centers are involved in the survey. A diagnosis of BTP was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage of disease, presence and sites of metastases, ongoing oncologic treatment, and characteristics of background pain and BTP and their treatments were recorded. Background pain and BTP intensity were measured. Patients were also questioned about BTP predictability, BTP onset (≤10 or >10 min), BTP duration, background and BTP medications and their doses, time to meaningful pain relief after BTP medication, and satisfaction with BTP medication. The occurrence of adverse reactions was also assessed, as well as mucosal toxicity. Results: Background pain was well controlled with opioid treatment (numerical rating scale 3.0 ± 1.1). Patients reported 2.5 ± 1.6 BTP episodes/day with a mean intensity of 7.5 ± 1.4 and duration of 43 ± 40 min; 977 patients (65.1%) reported non-predictable BTP, and 1076 patients (71.7%) reported a rapid onset of BTP (≤10 min). Higher patient satisfaction was reported by patients treated with fast onset opioids. Conclusions: These preliminary data underline that the standard algorithm used is a valid tool for a proper diagnosis of BTP in cancer patients. Moreover, rapid relief of pain is crucial for patients’ satisfaction. The final IOPS-MS data are necessary to understand relationships between BTP characteristics and other clinical variables in oncologic patients. Funding: Molteni Farmaceutici, Italy.

Original language	English
Pages (from-to)	1-16
Number of pages	16
Journal	Advances in Therapy
DOIs	https://doi.org/10.1007/s12325-016-0440-4
Publication status	Published - 2017

Keywords

Breakthrough pain
Cancer pain
Pain assessment
Rapid-onset opioid

ASJC Scopus subject areas

Medicine(all)
Pharmacology (medical)

Access to Document

10.1007/s12325-016-0440-4

Cite this

Mercadante, S., Cuomo, A., Caraceni, A., Mediati, R. D., Mammucari, M., Natoli, S., Lazzari, M., Dauri, M., Airoldi, M., Azzarello, G., Bandera, M., Blasi, L., Cartenì, G., Chiurazzi, B., Costanzo, B. V. P., Degiovanni, D., Fusco, F., Guardamagna, V., Iaffaioli, R. V., ... Saber, B. (2017). Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS). Advances in Therapy, 1-16. https://doi.org/10.1007/s12325-016-0440-4

Mercadante, S, Cuomo, A, Caraceni, A, Mediati, RD, Mammucari, M, Natoli, S, Lazzari, M, Dauri, M, Airoldi, M, Azzarello, G, Bandera, M, Blasi, L, Cartenì, G, Chiurazzi, B, Costanzo, BVP, Degiovanni, D, Fusco, F, Guardamagna, V, Iaffaioli, RV, Liguori, S, Lorusso, V, Mameli, S, Mattioli, R, Mazzei, T, Melotti, RM, Menardo, V, Miotti, D, Moroso, S, de Santis, S, Orsetti, R, Papa, A, Ricci, S, Sabato, AF, Scelzi, E, Sofia, M, Tonini, G, Aielli, F, Valle, A, Angelini, S, Iacono, D, Mazzuca, F, Carnevale, A, Bonome, P, Nicosia, L, Scaringi, C, Montalto, A, Russo, G, Forte, CA, Esposito, G, Bracchi, P, Zecca, E, Campa, T, Grecchi, S, Pigni, A, Sammaro, A, Dodaro, L, Ballerini, G, Vellucci, R, Caldarulo, C, Palombo, E, Diviza, M, Gianfelice, V, Silvestri, C, Finocchi, S, Contu, V, Fora, G, Pedani, F, Icardi, M, Bellini, E, Celano, A, Berardo, R, Ostellino, O, Sartori, K, Demartini, P, Scroccaro, R, Boscolo, G, Sartori, D, Rosetti, F, Artioli, G, Borgato, L, Bertoldero, G, Veronese, B, Vallini, I, Tuzi, A, Bolzacchini, E, Pinotti, G, Alù, M, Usset, A, Arcuri, C, Laudani, A, Pepe, A, Scagliarini, S, Sgarlata, MSM, Raimondi, M, Valenti, SMG, Bucceri, A, Kasa, A, Budel, P, Caramellino, A, Ballarino, P, Donelli, E, Silvestro, S, Tonetti, R, Bozzoni, S, Cocquio, A, Romano, C, Nappi, A, De Divitiis, C, Ghidoni, S, Cortinovis, R, Marchesi, R, Fortis, M, Palermo, L, Pisanu, GM, Carboni, M, Meloni, F, Barillari, D, Imperatori, L, Grilli, G, Laici, G, Diacciati, S, Petreni, P, Samolsky Dekel, B, Marsigli, F, Manfreda, M, Ghedini, S, Bruno, E, Salvini, E, Gerboni, D, Saulle, S, Carella, R, Pascoletti, G, Bolzonello, S, Bonotto, M, Ellero, S, Fasola, G, Ongaro, E, Borghesi, C, Germani, L, de Ruvo, E, Marchetti, F, Pasquale, M, Masu, L, Tammaro, D, Saracco, E, Di Dato, MT, Ferrara, M, Pironti, A, Buonavolontà, P, Ginocchi, L, Musettini, G, Antonuzzo, A, Caparello, C, Lucchesi, M, Farnesi, A, Zampieri, M, Pisciotta, M, Fioroni, I, Ratta, R, Cursano, MC, Santini, D, Potestà, C, Gallo, G & Saber, B 2017, 'Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)', Advances in Therapy, pp. 1-16. https://doi.org/10.1007/s12325-016-0440-4

@article{a7a9d58bdd3246919a0f3900bf9dd424,

title = "Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)",

abstract = "Introduction: An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here. Methods: Thirty-two clinical centers are involved in the survey. A diagnosis of BTP was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage of disease, presence and sites of metastases, ongoing oncologic treatment, and characteristics of background pain and BTP and their treatments were recorded. Background pain and BTP intensity were measured. Patients were also questioned about BTP predictability, BTP onset (≤10 or >10 min), BTP duration, background and BTP medications and their doses, time to meaningful pain relief after BTP medication, and satisfaction with BTP medication. The occurrence of adverse reactions was also assessed, as well as mucosal toxicity. Results: Background pain was well controlled with opioid treatment (numerical rating scale 3.0 ± 1.1). Patients reported 2.5 ± 1.6 BTP episodes/day with a mean intensity of 7.5 ± 1.4 and duration of 43 ± 40 min; 977 patients (65.1%) reported non-predictable BTP, and 1076 patients (71.7%) reported a rapid onset of BTP (≤10 min). Higher patient satisfaction was reported by patients treated with fast onset opioids. Conclusions: These preliminary data underline that the standard algorithm used is a valid tool for a proper diagnosis of BTP in cancer patients. Moreover, rapid relief of pain is crucial for patients{\textquoteright} satisfaction. The final IOPS-MS data are necessary to understand relationships between BTP characteristics and other clinical variables in oncologic patients. Funding: Molteni Farmaceutici, Italy.",

keywords = "Breakthrough pain, Cancer pain, Pain assessment, Rapid-onset opioid",

author = "Sebastiano Mercadante and Arturo Cuomo and Augusto Caraceni and Mediati, {Rocco D.} and Massimo Mammucari and Silvia Natoli and Marzia Lazzari and Mario Dauri and M. Airoldi and Giuseppe Azzarello and Mauro Bandera and Livio Blasi and Giacomo Carten{\`i} and B. Chiurazzi and Costanzo, {Benedetta Veruska Pierpaola} and D. Degiovanni and Flavio Fusco and Vittorio Guardamagna and Iaffaioli, {Rosario Vincenzo} and S. Liguori and Vito Lorusso and Sergio Mameli and Rodolfo Mattioli and Teresita Mazzei and Melotti, {Rita M.} and Valentino Menardo and Danilo Miotti and Stefano Moroso and {de Santis}, Stefano and R. Orsetti and Alfonso Papa and Sergio Ricci and Sabato, {Alessandro F.} and E. Scelzi and Michele Sofia and Giuseppe Tonini and Federica Aielli and Alessandro Valle and Silvia Angelini and Daniela Iacono and Federica Mazzuca and Alessia Carnevale and Paolo Bonome and Luca Nicosia and Claudia Scaringi and Adelaide Montalto and G. Russo and Forte, {Cira Antonietta} and Gennaro Esposito and Paola Bracchi and Ernesto Zecca and Tiziana Campa and Silvia Grecchi and Alessandra Pigni and Annunziata Sammaro and Lucia Dodaro and Giovanna Ballerini and Renato Vellucci and Clarissa Caldarulo and E. Palombo and Marco Diviza and Valentina Gianfelice and Claudia Silvestri and Simona Finocchi and Viviana Contu and Gianluca Fora and Fulvia Pedani and Massimiliano Icardi and Elisa Bellini and Alfredo Celano and Roberto Berardo and Oliviero Ostellino and Kayta Sartori and Paola Demartini and Raffaella Scroccaro and Giorgia Boscolo and Donata Sartori and Francesco Rosetti and G. Artioli and L. Borgato and Giovanni Bertoldero and Barbara Veronese and Ilaria Vallini and Alessandro Tuzi and Elena Bolzacchini and G. Pinotti and Massimiliano Al{\`u} and A. Usset and Carmela Arcuri and Agata Laudani and Alessio Pepe and Sarah Scagliarini and Sgarlata, {Massimiliano Savio Maria} and Massimo Raimondi and Valenti, {Salvatore Maria Giovanni} and Alberto Bucceri and Alma Kasa and Paola Budel and Anna Caramellino and Paola Ballarino and E. Donelli and Stefania Silvestro and Rossella Tonetti and S. Bozzoni and Angela Cocquio and Carmela Romano and Anna Nappi and {De Divitiis}, Chiara and Silvia Ghidoni and Rosalba Cortinovis and Roberta Marchesi and Michele Fortis and Loredana Palermo and Pisanu, {Giovanni Maria} and Maura Carboni and Francesca Meloni and Daniele Barillari and Luca Imperatori and Gianni Grilli and G. Laici and Sara Diacciati and P. Petreni and {Samolsky Dekel}, Boaz and Federica Marsigli and Miriam Manfreda and Silvia Ghedini and Emanuela Bruno and Emanuele Salvini and Davide Gerboni and Serena Saulle and Roberta Carella and Gaetano Pascoletti and Silvia Bolzonello and Marta Bonotto and Silvia Ellero and Gianpiero Fasola and Elena Ongaro and Cristina Borghesi and Lucia Germani and {de Ruvo}, Edoardo and Federica Marchetti and Milena Pasquale and Lucia Masu and Dario Tammaro and Elisabetta Saracco and {Di Dato}, {Maria Teresa} and Maurizio Ferrara and Andrea Pironti and Pietro Buonavolont{\`a} and Laura Ginocchi and Gianna Musettini and Andrea Antonuzzo and C. Caparello and Maurizio Lucchesi and Azzurra Farnesi and Mari Zampieri and Manuela Pisciotta and Iacopo Fioroni and Raffaele Ratta and Cursano, {Maria Concetta} and Daniele Santini and Cinzia Potest{\`a} and Gloria Gallo and Benhaz Saber",

year = "2017",

doi = "10.1007/s12325-016-0440-4",

language = "English",

pages = "1--16",

journal = "Advances in Therapy",

issn = "0741-238X",

publisher = "Springer Healthcare",

}

TY - JOUR

T1 - Breakthrough Cancer Pain

T2 - Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

AU - Mercadante, Sebastiano

AU - Cuomo, Arturo

AU - Caraceni, Augusto

AU - Mediati, Rocco D.

AU - Mammucari, Massimo

AU - Natoli, Silvia

AU - Lazzari, Marzia

AU - Dauri, Mario

AU - Airoldi, M.

AU - Azzarello, Giuseppe

AU - Bandera, Mauro

AU - Blasi, Livio

AU - Cartenì, Giacomo

AU - Chiurazzi, B.

AU - Costanzo, Benedetta Veruska Pierpaola

AU - Degiovanni, D.

AU - Fusco, Flavio

AU - Guardamagna, Vittorio

AU - Iaffaioli, Rosario Vincenzo

AU - Liguori, S.

AU - Lorusso, Vito

AU - Mameli, Sergio

AU - Mattioli, Rodolfo

AU - Mazzei, Teresita

AU - Melotti, Rita M.

AU - Menardo, Valentino

AU - Miotti, Danilo

AU - Moroso, Stefano

AU - de Santis, Stefano

AU - Orsetti, R.

AU - Papa, Alfonso

AU - Ricci, Sergio

AU - Sabato, Alessandro F.

AU - Scelzi, E.

AU - Sofia, Michele

AU - Tonini, Giuseppe

AU - Aielli, Federica

AU - Valle, Alessandro

AU - Angelini, Silvia

AU - Iacono, Daniela

AU - Mazzuca, Federica

AU - Carnevale, Alessia

AU - Bonome, Paolo

AU - Nicosia, Luca

AU - Scaringi, Claudia

AU - Montalto, Adelaide

AU - Russo, G.

AU - Forte, Cira Antonietta

AU - Esposito, Gennaro

AU - Bracchi, Paola

AU - Zecca, Ernesto

AU - Campa, Tiziana

AU - Grecchi, Silvia

AU - Pigni, Alessandra

AU - Sammaro, Annunziata

AU - Dodaro, Lucia

AU - Ballerini, Giovanna

AU - Vellucci, Renato

AU - Caldarulo, Clarissa

AU - Palombo, E.

AU - Diviza, Marco

AU - Gianfelice, Valentina

AU - Silvestri, Claudia

AU - Finocchi, Simona

AU - Contu, Viviana

AU - Fora, Gianluca

AU - Pedani, Fulvia

AU - Icardi, Massimiliano

AU - Bellini, Elisa

AU - Celano, Alfredo

AU - Berardo, Roberto

AU - Ostellino, Oliviero

AU - Sartori, Kayta

AU - Demartini, Paola

AU - Scroccaro, Raffaella

AU - Boscolo, Giorgia

AU - Sartori, Donata

AU - Rosetti, Francesco

AU - Artioli, G.

AU - Borgato, L.

AU - Bertoldero, Giovanni

AU - Veronese, Barbara

AU - Vallini, Ilaria

AU - Tuzi, Alessandro

AU - Bolzacchini, Elena

AU - Pinotti, G.

AU - Alù, Massimiliano

AU - Usset, A.

AU - Arcuri, Carmela

AU - Laudani, Agata

AU - Pepe, Alessio

AU - Scagliarini, Sarah

AU - Sgarlata, Massimiliano Savio Maria

AU - Raimondi, Massimo

AU - Valenti, Salvatore Maria Giovanni

AU - Bucceri, Alberto

AU - Kasa, Alma

AU - Budel, Paola

AU - Caramellino, Anna

AU - Ballarino, Paola

AU - Donelli, E.

AU - Silvestro, Stefania

AU - Tonetti, Rossella

AU - Bozzoni, S.

AU - Cocquio, Angela

AU - Romano, Carmela

AU - Nappi, Anna

AU - De Divitiis, Chiara

AU - Ghidoni, Silvia

AU - Cortinovis, Rosalba

AU - Marchesi, Roberta

AU - Fortis, Michele

AU - Palermo, Loredana

AU - Pisanu, Giovanni Maria

AU - Carboni, Maura

AU - Meloni, Francesca

AU - Barillari, Daniele

AU - Imperatori, Luca

AU - Grilli, Gianni

AU - Laici, G.

AU - Diacciati, Sara

AU - Petreni, P.

AU - Samolsky Dekel, Boaz

AU - Marsigli, Federica

AU - Manfreda, Miriam

AU - Ghedini, Silvia

AU - Bruno, Emanuela

AU - Salvini, Emanuele

AU - Gerboni, Davide

AU - Saulle, Serena

AU - Carella, Roberta

AU - Pascoletti, Gaetano

AU - Bolzonello, Silvia

AU - Bonotto, Marta

AU - Ellero, Silvia

AU - Fasola, Gianpiero

AU - Ongaro, Elena

AU - Borghesi, Cristina

AU - Germani, Lucia

AU - de Ruvo, Edoardo

AU - Marchetti, Federica

AU - Pasquale, Milena

AU - Masu, Lucia

AU - Tammaro, Dario

AU - Saracco, Elisabetta

AU - Di Dato, Maria Teresa

AU - Ferrara, Maurizio

AU - Pironti, Andrea

AU - Buonavolontà, Pietro

AU - Ginocchi, Laura

AU - Musettini, Gianna

AU - Antonuzzo, Andrea

AU - Caparello, C.

AU - Lucchesi, Maurizio

AU - Farnesi, Azzurra

AU - Zampieri, Mari

AU - Pisciotta, Manuela

AU - Fioroni, Iacopo

AU - Ratta, Raffaele

AU - Cursano, Maria Concetta

AU - Santini, Daniele

AU - Potestà, Cinzia

AU - Gallo, Gloria

AU - Saber, Benhaz

PY - 2017

Y1 - 2017

N2 - Introduction: An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here. Methods: Thirty-two clinical centers are involved in the survey. A diagnosis of BTP was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage of disease, presence and sites of metastases, ongoing oncologic treatment, and characteristics of background pain and BTP and their treatments were recorded. Background pain and BTP intensity were measured. Patients were also questioned about BTP predictability, BTP onset (≤10 or >10 min), BTP duration, background and BTP medications and their doses, time to meaningful pain relief after BTP medication, and satisfaction with BTP medication. The occurrence of adverse reactions was also assessed, as well as mucosal toxicity. Results: Background pain was well controlled with opioid treatment (numerical rating scale 3.0 ± 1.1). Patients reported 2.5 ± 1.6 BTP episodes/day with a mean intensity of 7.5 ± 1.4 and duration of 43 ± 40 min; 977 patients (65.1%) reported non-predictable BTP, and 1076 patients (71.7%) reported a rapid onset of BTP (≤10 min). Higher patient satisfaction was reported by patients treated with fast onset opioids. Conclusions: These preliminary data underline that the standard algorithm used is a valid tool for a proper diagnosis of BTP in cancer patients. Moreover, rapid relief of pain is crucial for patients’ satisfaction. The final IOPS-MS data are necessary to understand relationships between BTP characteristics and other clinical variables in oncologic patients. Funding: Molteni Farmaceutici, Italy.

AB - Introduction: An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here. Methods: Thirty-two clinical centers are involved in the survey. A diagnosis of BTP was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage of disease, presence and sites of metastases, ongoing oncologic treatment, and characteristics of background pain and BTP and their treatments were recorded. Background pain and BTP intensity were measured. Patients were also questioned about BTP predictability, BTP onset (≤10 or >10 min), BTP duration, background and BTP medications and their doses, time to meaningful pain relief after BTP medication, and satisfaction with BTP medication. The occurrence of adverse reactions was also assessed, as well as mucosal toxicity. Results: Background pain was well controlled with opioid treatment (numerical rating scale 3.0 ± 1.1). Patients reported 2.5 ± 1.6 BTP episodes/day with a mean intensity of 7.5 ± 1.4 and duration of 43 ± 40 min; 977 patients (65.1%) reported non-predictable BTP, and 1076 patients (71.7%) reported a rapid onset of BTP (≤10 min). Higher patient satisfaction was reported by patients treated with fast onset opioids. Conclusions: These preliminary data underline that the standard algorithm used is a valid tool for a proper diagnosis of BTP in cancer patients. Moreover, rapid relief of pain is crucial for patients’ satisfaction. The final IOPS-MS data are necessary to understand relationships between BTP characteristics and other clinical variables in oncologic patients. Funding: Molteni Farmaceutici, Italy.

KW - Breakthrough pain

KW - Cancer pain

KW - Pain assessment

KW - Rapid-onset opioid

UR - http://www.scopus.com/inward/record.url?scp=84996836207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84996836207&partnerID=8YFLogxK

U2 - 10.1007/s12325-016-0440-4

DO - 10.1007/s12325-016-0440-4

M3 - Article

SN - 0741-238X

SP - 1

EP - 16

JO - Advances in Therapy

JF - Advances in Therapy

ER -

Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

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