TY - JOUR
T1 - Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury
AU - Aquilani, Roberto
AU - Iadarola, Paolo
AU - Contardi, Antonella
AU - Boselli, Mirella
AU - Verri, Manuela
AU - Pastoris, Ornella
AU - Boschi, Federica
AU - Arcidiaco, Patrizia
AU - Viglio, Simona
PY - 2005/9
Y1 - 2005/9
N2 - Objective: To investigate whether supplementation with branched-chain amino acids (BCAAs) in patients with severe traumatic brain injury (TBI) improves recovery of cognition and influences plasma concentrations of tyrosine and tryptophan, which are precursors of, respectively, catecholamine and serotonin neurotransmitters in the brain. Design: Forty patients with TBI were randomly assigned to 15 days of intravenous BCAA supplementation (19.6g/d) (n=20) or an isonitrogenous placebo (n=20). Setting: Tertiary care rehabilitation setting in Italy. Participants: Forty men (mean age, 32±15y) with TBI and 20 healthy subjects (controls) matched for age, sex, and sedentary lifestyle. Intervention: Supplementation with BCAAs. Main Outcome Measures: Disability Rating Scale (DRS) and plasma concentrations of BCAAs, tyrosine, and tryptophan. Results: Fifteen days after admission to the rehabilitation department, the DRS score had improved significantly in both the placebo group (P
AB - Objective: To investigate whether supplementation with branched-chain amino acids (BCAAs) in patients with severe traumatic brain injury (TBI) improves recovery of cognition and influences plasma concentrations of tyrosine and tryptophan, which are precursors of, respectively, catecholamine and serotonin neurotransmitters in the brain. Design: Forty patients with TBI were randomly assigned to 15 days of intravenous BCAA supplementation (19.6g/d) (n=20) or an isonitrogenous placebo (n=20). Setting: Tertiary care rehabilitation setting in Italy. Participants: Forty men (mean age, 32±15y) with TBI and 20 healthy subjects (controls) matched for age, sex, and sedentary lifestyle. Intervention: Supplementation with BCAAs. Main Outcome Measures: Disability Rating Scale (DRS) and plasma concentrations of BCAAs, tyrosine, and tryptophan. Results: Fifteen days after admission to the rehabilitation department, the DRS score had improved significantly in both the placebo group (P
KW - Amino acids, branched-chain
KW - Brain injuries
KW - Rehabilitation
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U2 - 10.1016/j.apmr.2005.03.022
DO - 10.1016/j.apmr.2005.03.022
M3 - Article
C2 - 16181934
AN - SCOPUS:25144525057
SN - 0003-9993
VL - 86
SP - 1729
EP - 1735
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 9
ER -