Brain β-endorphin concentrations in experimental chronic liver disease

A. E. Panerai; F. Salerno; F. Baldissera; A. Martini; A. M. Di Giulio; P. Mantegazza

doi:10.1016/0006-8993(82)91049-6

Brain β-endorphin concentrations in experimental chronic liver disease

A. E. Panerai, F. Salerno, F. Baldissera, A. Martini, A. M. Di Giulio, P. Mantegazza

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

β-Endorphin, Met-enkephalin, substance P and somatostatin concentrations have been evaluated in brain areas of rats with severe liver disease obtained by chronic pretreatment with CCl₄ for 3 or 9 weeks. β-Endorphin, but not Met-enkephalin, somatostatin or substance P concentrations were significantly decreased in the hypothalamus of both the three and nine week-treatment groups. The β-endorphin decrease we observed might be tentatively attributed to a modification of GABA levels, but not serotonin, since the stimulation of the serotoninergic system induced a significant increase, while the potentiation of the GABAergic system induced a clear decrease of β-endorphin concentrations in the hypothalamus of treated rats.

Original language	English
Pages (from-to)	188-190
Number of pages	3
Journal	Brain Research
Volume	247
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(82)91049-6
Publication status	Published - Sept 9 1982

Keywords

liver disease
β-endorphin

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(82)91049-6

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title = "Brain β-endorphin concentrations in experimental chronic liver disease",

abstract = "β-Endorphin, Met-enkephalin, substance P and somatostatin concentrations have been evaluated in brain areas of rats with severe liver disease obtained by chronic pretreatment with CCl4 for 3 or 9 weeks. β-Endorphin, but not Met-enkephalin, somatostatin or substance P concentrations were significantly decreased in the hypothalamus of both the three and nine week-treatment groups. The β-endorphin decrease we observed might be tentatively attributed to a modification of GABA levels, but not serotonin, since the stimulation of the serotoninergic system induced a significant increase, while the potentiation of the GABAergic system induced a clear decrease of β-endorphin concentrations in the hypothalamus of treated rats.",

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T1 - Brain β-endorphin concentrations in experimental chronic liver disease

AU - Panerai, A. E.

AU - Salerno, F.

AU - Baldissera, F.

AU - Martini, A.

AU - Di Giulio, A. M.

AU - Mantegazza, P.

PY - 1982/9/9

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N2 - β-Endorphin, Met-enkephalin, substance P and somatostatin concentrations have been evaluated in brain areas of rats with severe liver disease obtained by chronic pretreatment with CCl4 for 3 or 9 weeks. β-Endorphin, but not Met-enkephalin, somatostatin or substance P concentrations were significantly decreased in the hypothalamus of both the three and nine week-treatment groups. The β-endorphin decrease we observed might be tentatively attributed to a modification of GABA levels, but not serotonin, since the stimulation of the serotoninergic system induced a significant increase, while the potentiation of the GABAergic system induced a clear decrease of β-endorphin concentrations in the hypothalamus of treated rats.

AB - β-Endorphin, Met-enkephalin, substance P and somatostatin concentrations have been evaluated in brain areas of rats with severe liver disease obtained by chronic pretreatment with CCl4 for 3 or 9 weeks. β-Endorphin, but not Met-enkephalin, somatostatin or substance P concentrations were significantly decreased in the hypothalamus of both the three and nine week-treatment groups. The β-endorphin decrease we observed might be tentatively attributed to a modification of GABA levels, but not serotonin, since the stimulation of the serotoninergic system induced a significant increase, while the potentiation of the GABAergic system induced a clear decrease of β-endorphin concentrations in the hypothalamus of treated rats.

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Brain β-endorphin concentrations in experimental chronic liver disease

Abstract

Keywords

ASJC Scopus subject areas

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