Brain β-endorphin concentrations in experimental chronic liver disease

A. E. Panerai, F. Salerno, F. Baldissera, A. Martini, A. M. Di Giulio, P. Mantegazza

Research output: Contribution to journalArticlepeer-review


β-Endorphin, Met-enkephalin, substance P and somatostatin concentrations have been evaluated in brain areas of rats with severe liver disease obtained by chronic pretreatment with CCl4 for 3 or 9 weeks. β-Endorphin, but not Met-enkephalin, somatostatin or substance P concentrations were significantly decreased in the hypothalamus of both the three and nine week-treatment groups. The β-endorphin decrease we observed might be tentatively attributed to a modification of GABA levels, but not serotonin, since the stimulation of the serotoninergic system induced a significant increase, while the potentiation of the GABAergic system induced a clear decrease of β-endorphin concentrations in the hypothalamus of treated rats.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalBrain Research
Issue number1
Publication statusPublished - Sept 9 1982


  • liver disease
  • β-endorphin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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