Brain networks stimulation in dementia: insights from functional imaging

Michela Pievani, Lorenzo Pini, Stefano Cappa, Giovanni B. Frisoni

Research output: Contribution to journalArticlepeer-review


PURPOSE OF REVIEW: Noninvasive brain stimulation (NIBS) is increasingly used in the field of dementia as a therapeutic option; however, evidence of clinical efficacy is limited, and the mechanism of action remains unknown. This review summarizes how functional imaging could contribute to the design of targeted and effective NIBS interventions for dementia. RECENT FINDINGS: Resting-state functional magnetic resonance imaging (fMRI) has largely contributed to understanding brain dysfunction in dementia by identifying disease-specific networks. Resting-state fMRI might inform on a number of factors critical for the conduction of effective NIBS trials, such as definition of stimulation paradigms and choice of the stimulation target. In addition, fMRI may contribute to the understanding of the mechanisms of action of NIBS, and provide a tool to monitor treatment efficacy. SUMMARY: Functional imaging is a promising approach for the development of hypothesis-driven, targeted stimulation approaches in the field of dementia.

Original languageEnglish
Pages (from-to)756-762
JournalCurrent Opinion in Neurology
Issue number6
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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