Brain flow changes before and after deep brain stimulation of the subthalamic nucleus in Parkinson's disease

A. Antonini; G. Marotta; R. Benti; A. Landi; R. De Notaris; C. Mariani; P. Gerundini; G. Pezzoli; S. M. Gaini

doi:10.1007/s10072-003-0104-4

Brain flow changes before and after deep brain stimulation of the subthalamic nucleus in Parkinson's disease

A. Antonini, G. Marotta, R. Benti, A. Landi, R. De Notaris, C. Mariani, P. Gerundini, G. Pezzoli, S. M. Gaini

Research output: Contribution to journal › Article › peer-review

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) markedly improves motor symptoms and reduces medication needs in Parkinson's disease (PD) patients. However, its effect on brain function has remained unclear. We used SPECT and the tracer ECD to measure regional cerebral blood flow before and 6 months after DBS of the STN in 22 PD patients and 13 healthy controls. PD patients were divided into good and poor responders to DBS, if changes in "off" UPDRS motor scores after surgery were >60% or

Original language	English
Pages (from-to)	151-152
Number of pages	2
Journal	Neurological Sciences
Volume	24
Issue number	3
DOIs	https://doi.org/10.1007/s10072-003-0104-4
Publication status	Published - Oct 2003

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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AU - De Notaris, R.

AU - Mariani, C.

AU - Gerundini, P.

AU - Pezzoli, G.

AU - Gaini, S. M.

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AB - Deep brain stimulation (DBS) of the subthalamic nucleus (STN) markedly improves motor symptoms and reduces medication needs in Parkinson's disease (PD) patients. However, its effect on brain function has remained unclear. We used SPECT and the tracer ECD to measure regional cerebral blood flow before and 6 months after DBS of the STN in 22 PD patients and 13 healthy controls. PD patients were divided into good and poor responders to DBS, if changes in "off" UPDRS motor scores after surgery were >60% or

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Brain flow changes before and after deep brain stimulation of the subthalamic nucleus in Parkinson's disease

Abstract

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