Brain diseases and tumorigenesis: The good and bad cops of pentraxin3

Francesco Fornai, Albino Carrizzo, Michela Ferrucci, Antonio Damato, Francesca Biagioni, Anderson Gaglione, Annibale Alessandro Puca, Carmine Vecchione

Research output: Contribution to journalArticlepeer-review


The prototype of long pentraxins, Pentraxin 3 (PTX3), is an evolutionarily conserved multifunctional, pattern-recognition protein constituted by a cyclic multimeric structure. PTX3 interacts with a variety of ligands, such as growth factors, extracellular matrix components, molecules of the complement cascade, pathogens recognition proteins, angiogenetic and adhesion molecules. PTX3 could be considered as a molecular link between innate and adaptive immunity as well as between focal and circulating responses during inflammation. In fact, it modulates the functions of resident dendritic cells and circulating lymphocytes. Recent evidence demonstrates that manipulation of PTX3 may produce even opposite effects depending on which target organ is considered and the physiopathological context. In the present review we discuss the good and bad cops of PTX3 concerning multifacted effects on inflammation, innate immunity, brain diseases and tumorigenesis. Finally, a perspective on PTX3 and autophagy is provided as a convergent pathway.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Publication statusPublished - Dec 1 2015


  • Brain
  • Inflammation
  • Pentraxin3
  • Tumor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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