BRAF in papillary thyroid carcinoma

Salvatore Giovanni Lanzilotta; Luciano Grammatica; Angelo Paradiso; Gianni Simone

BRAF in papillary thyroid carcinoma

Salvatore Giovanni Lanzilotta, Luciano Grammatica, Angelo Paradiso, Gianni Simone

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

Novel genetic findings about papillary thyroid carcinoma identify BRAF gene as a subject of great interest. Involvement of BRAF gene in pathogenesis of PTC, diagnostic value and the putative prognostic significance of its T1799A mutation are summarized in this article. Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.

Original language	English
Pages (from-to)	269-277
Number of pages	9
Journal	Cellular Oncology
Volume	29
Issue number	4
Publication status	Published - 2007

Keywords

BRAF mutation
Fine-needle aspiration
Papillary thyroid cancer

ASJC Scopus subject areas

Cell Biology
Oncology
Pathology and Forensic Medicine

Cite this

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AU - Lanzilotta, Salvatore Giovanni

AU - Grammatica, Luciano

AU - Paradiso, Angelo

AU - Simone, Gianni

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N2 - Novel genetic findings about papillary thyroid carcinoma identify BRAF gene as a subject of great interest. Involvement of BRAF gene in pathogenesis of PTC, diagnostic value and the putative prognostic significance of its T1799A mutation are summarized in this article. Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.

AB - Novel genetic findings about papillary thyroid carcinoma identify BRAF gene as a subject of great interest. Involvement of BRAF gene in pathogenesis of PTC, diagnostic value and the putative prognostic significance of its T1799A mutation are summarized in this article. Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.

KW - BRAF mutation

KW - Fine-needle aspiration

KW - Papillary thyroid cancer

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BRAF in papillary thyroid carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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