Botulinum toxin for chronic anal fissure

D. Gui, G. Anastasio, G. Maria, E. Cassetta, A. R. Bentivoglio, A. Albanese

Research output: Contribution to journalArticlepeer-review


Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day was observed in one patient. We propose that botulinum toxin injections in the internal anal sphincter be considered an alternative approach to surgical therapy of anal fissure.

Original languageEnglish
Pages (from-to)1127-1128
Number of pages2
Issue number8930
Publication statusPublished - Oct 22 1994

ASJC Scopus subject areas

  • Medicine(all)


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