TY - JOUR
T1 - Bortezomib as salvage treatment for heavily pretreated relapsed lymphoma patients
T2 - A multicenter retrospective study
AU - Zinzani, Pier Luigi
AU - Pellegrini, Cinzia
AU - Merla, Emanuela
AU - Ballerini, Filippo
AU - Fabbri, Alberto
AU - Guarini, Attilio
AU - Pavone, Vincenzo
AU - Quintini, Gerlando
AU - Puccini, Benedetta
AU - Vigliotti, Maria Luigia
AU - Stefoni, Vittorio
AU - Derenzini, Enrico
AU - Broccoli, Alessandro
AU - Gandolfi, Letizia
AU - Quirini, Federica
AU - Casadei, Beatrice
AU - Argnani, Lisa
AU - Baccarani, Michele
PY - 2013/12
Y1 - 2013/12
N2 - Current treatments for non-Hodgkin lymphomas are not optimally effective. Among new agents, bortezomib seems to play a pivotal role in the regulation of several cell pathways involved in the development of lymphomas. After results were obtained with clinical trials, we aimed to observe treatment with bortezomib in everyday clinical practice. We performed a multicenter retrospective analysis to assess the efficacy of bortezomib in heavily pretreated (median number of previous therapies 4, range 2-6) lymphoma patients in an off-label setting. Bortezomib therapy was scheduled for 4-6 cycles (1.3mg/m2 biweekly). Data from 50 patients were collected: 22% had a complete remission, 26% obtained a partial response and the remaining 52% was non-responder. According to histotype, we observed an overall response rate (ORR) of 51.6% in mantle cell lymphomas, an ORR of 60% among follicular lymphoma patients, and an ORR of 50% in the indolent nonfollicular lymphomas. None of diffuse large B-cell lymphoma patients obtained a response. Extra-hematological toxicity was really mild, and peripheral neuropathy occurred in only 5 patients; hematological toxicity was grades 3-4 thrombocytopenia in nine patients and grades 3-4 neutropenia in only three patients. In conclusion, treatment with bortezomib as single agent resulted safe and effective in a subset of heavily pretreated lymphoma patients with usually poor outcome. New future hypotheses of investigation are indicated.
AB - Current treatments for non-Hodgkin lymphomas are not optimally effective. Among new agents, bortezomib seems to play a pivotal role in the regulation of several cell pathways involved in the development of lymphomas. After results were obtained with clinical trials, we aimed to observe treatment with bortezomib in everyday clinical practice. We performed a multicenter retrospective analysis to assess the efficacy of bortezomib in heavily pretreated (median number of previous therapies 4, range 2-6) lymphoma patients in an off-label setting. Bortezomib therapy was scheduled for 4-6 cycles (1.3mg/m2 biweekly). Data from 50 patients were collected: 22% had a complete remission, 26% obtained a partial response and the remaining 52% was non-responder. According to histotype, we observed an overall response rate (ORR) of 51.6% in mantle cell lymphomas, an ORR of 60% among follicular lymphoma patients, and an ORR of 50% in the indolent nonfollicular lymphomas. None of diffuse large B-cell lymphoma patients obtained a response. Extra-hematological toxicity was really mild, and peripheral neuropathy occurred in only 5 patients; hematological toxicity was grades 3-4 thrombocytopenia in nine patients and grades 3-4 neutropenia in only three patients. In conclusion, treatment with bortezomib as single agent resulted safe and effective in a subset of heavily pretreated lymphoma patients with usually poor outcome. New future hypotheses of investigation are indicated.
KW - Bortezomib
KW - Observational
KW - Relapsed lymphoma
KW - Retrospective
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U2 - 10.1002/hon.2036
DO - 10.1002/hon.2036
M3 - Article
C2 - 23108928
AN - SCOPUS:84889084747
SN - 0278-0232
VL - 31
SP - 179
EP - 182
JO - Hematological Oncology
JF - Hematological Oncology
IS - 4
ER -