Bone Metabolism in Celiac Disease

Chiara Zanchi, Grazia Di Leo, Luca Ronfani, Stefano Martelossi, Tarcisio Not, Alessandro Ventura

Research output: Contribution to journalArticlepeer-review


Objective: To investigate the prevalence of both calcium metabolism alterations and bone defects in children with celiac disease (CD). Study design: We studied 54 untreated patients with CD (mean age, 7 years). We compared the serum concentration of calcium, magnesium, 25(OH)vitamin D3, alkaline phosphatase, and parathyroid hormone (PTH) of patients with CD with those of 60 healthy children. Children with CD with 2 laboratory alterations underwent DEXA examination, which was evaluated after 6 months of a gluten-free diet (GFD). Results: The calcium and the 25(OH)vitamin D3 levels were lower in children with CD than in control subjects, and the PTH level was higher in children with CD than in control subjects (P <.001). Hyperparathyroidism was found in 29 children with CD. Twenty patients tested positive for 2 laboratory alterations, and 10 of them were osteopenic. After 6 months of GFD calcium, 25(OH)vit.D3 and PTH levels normalized, with the improvement of bone mineral density. Conclusions: Calcium metabolism defects are common in untreated children with CD, and they returned to normal after GFD. A detailed, time-consuming, and expensive study of bone metabolism is not necessary in children with CD shortly exposed to gluten who follow the GFD.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalJournal of Pediatrics
Issue number2
Publication statusPublished - Aug 2008

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Bone Metabolism in Celiac Disease'. Together they form a unique fingerprint.

Cite this