Bone marrow and tissue expression of gpIIb/IIIa, LFA-1, Mac-1 and gp 150,95 glycoproteins

D. Soligo, G. Cattoretti, M. Colombi, N. Polli, F. Capsoni, F. Rilke, G. Lambertenghi Deliliers

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Monoclonal antibodies (MAbs) against platelet glycoproteins gpIIb/IIIa and the leucocyte adhesion molecules LFA-1, Mac-1, and gp 150,95 α chain (CD11a,b,c) and β chain (CD18) have been tested in normal and leukaemic bone marrow, in different human tissues, and in a patient with leucocyte adhesion deficiency (LAD). The effect of these Mabs on platelet aggregation was also tested. GpIIb/IIIa showed widespread distribution, while reactivity of CD11/18 antibodies was limited to haematopoietic cells. Platelets and megakaryocytes were reactive with one CD11a (25.5.2), and with no CD11b/c or CD18 MAbs. GpIIb/IIIa was present on the platelets of the patient with LAD, whereas 25.5.2, (CD11a) bound to his platelets but not to his leucocytes. These data indicate that LFA-1, Mac-1, and gp150,95 are not present on human platelets, but they suggest the existence of crossreacting epitopes on gpIIb/IIIa, which is consistent with the hypothesis that these molecules belong to a supergene family of adhesion molecules.

Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalEuropean Journal of Haematology
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Hematology


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