Bombesin inhibits growth hormone response to insulin-induced hypoglycemia in humans

Carmelo Scarpignato; Franco Tirelli; Antonio E. Pontiroli

doi:10.1016/0006-8993(86)90827-9

Bombesin inhibits growth hormone response to insulin-induced hypoglycemia in humans

Carmelo Scarpignato, Franco Tirelli, Antonio E. Pontiroli

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Intravenous administration of bombesin (5 ng/kg/min × 2.5 h) significantly reduced growth hormone (GH) response to insulin-induced (0.15 U/kg, i.v.) hypoglycemia in 8 male volunteers without affecting its basal plasma levels. These data, together with the presence of bombesin-like immunoreactivity in the human brain, suggest that - as in experimental animals - this neurogastrointestinal peptide may be of physiological significance in the control of GH secretion also in man.

Original language	English
Pages (from-to)	187-189
Number of pages	3
Journal	Brain Research
Volume	371
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)90827-9
Publication status	Published - Apr 16 1986

Keywords

bombesin
growth hormone
insulin hypoglycemia

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(86)90827-9

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abstract = "Intravenous administration of bombesin (5 ng/kg/min × 2.5 h) significantly reduced growth hormone (GH) response to insulin-induced (0.15 U/kg, i.v.) hypoglycemia in 8 male volunteers without affecting its basal plasma levels. These data, together with the presence of bombesin-like immunoreactivity in the human brain, suggest that - as in experimental animals - this neurogastrointestinal peptide may be of physiological significance in the control of GH secretion also in man.",

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AU - Scarpignato, Carmelo

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AU - Pontiroli, Antonio E.

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Y1 - 1986/4/16

N2 - Intravenous administration of bombesin (5 ng/kg/min × 2.5 h) significantly reduced growth hormone (GH) response to insulin-induced (0.15 U/kg, i.v.) hypoglycemia in 8 male volunteers without affecting its basal plasma levels. These data, together with the presence of bombesin-like immunoreactivity in the human brain, suggest that - as in experimental animals - this neurogastrointestinal peptide may be of physiological significance in the control of GH secretion also in man.

AB - Intravenous administration of bombesin (5 ng/kg/min × 2.5 h) significantly reduced growth hormone (GH) response to insulin-induced (0.15 U/kg, i.v.) hypoglycemia in 8 male volunteers without affecting its basal plasma levels. These data, together with the presence of bombesin-like immunoreactivity in the human brain, suggest that - as in experimental animals - this neurogastrointestinal peptide may be of physiological significance in the control of GH secretion also in man.

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KW - growth hormone

KW - insulin hypoglycemia

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Bombesin inhibits growth hormone response to insulin-induced hypoglycemia in humans

Abstract

Keywords

ASJC Scopus subject areas

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