BOLD signal sign and transient vessels volume variation

G. Garreffa, C. Colonnese, M. A. Macrì, N. Modugno, R. Rocca, V. Calistri, E. De Cesare, E. Venditti, B. Maraviglia

Research output: Contribution to journalArticlepeer-review


The purpose of this work was to investigate the relation between BOLD signal sign and transient vessels volume variation induced by apnea. This stimulus consisting of breath holding after inspiration is able to induce a light slowing down in venous blood flow like in a sort of Valsalva maneuver. We observed diffuse negative BOLD responding areas at cortical level and a stronger negative response in correspondence of the main sinuses. These phenomena seem to be unrelated to a specific neural activity, appearing to be expressions of a mechanical variation in the hemodynamics. Our study suggests that particular care must be considered in the interpretation of fMRI findings, especially when patients with vascular-related cerebral diseases are involved.

Original languageEnglish
Pages (from-to)1207-1212
Number of pages6
JournalMagnetic Resonance Imaging
Issue number10
Publication statusPublished - Dec 2003


  • Apnea
  • Functional MRI (fMRI)
  • Venous blood volume

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics


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