Blood pressure variability and organ damage in a general population: Results from the PAMELA study

Roberto Sega, Giovanni Corrao, Michele Bombelli, Luca Beltrame, Rita Facchetti, Guido Grassi, Marco Ferrario, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


In hypertensive patients, 24-hour blood pressure (BP) variability (V) shows a positive relationship with organ damage, organ damage progression, and cardiovascular morbidity. The clinical relevance of BPV in the population has never been investigated. In a sample of 3200 individuals, randomly selected from the general population of Monza (Milan, Italy), we evaluated BP by an automatic oscillometric device every 20 minutes for 24 hours and left ventricular mass index (LVMI) by echocardiography. In each subject, individual systolic and diastolic BP readings were averaged to obtain a 24-hour mean. Systolic BPV was obtained by calculating (1) the standard deviation of the 24-hour mean, which was taken as the overall BPV, (2) the cyclic components (Fourier spectral analysis) that in the population as a whole explained >95% of the overall BPV, and (3) the fraction of the overall BPV that in each subject was not accounted for by the 2 cyclic components, termed individual residual BPV. A similar procedure was used for diastolic BP and heart rate. Participation rate was 64.1%. Patients receiving antihypertensive therapy (n=403) were excluded from the analysis, which was therefore limited to 1648 participants. In the population as a whole, LVMI significantly related to 24-hour systolic and diastolic BP mean (β=0.40 and β=0.37, respectively, P

Original languageEnglish
Pages (from-to)710-714
Number of pages5
Issue number2 II
Publication statusPublished - 2002


  • Blood pressure
  • Blood pressure determination
  • Blood pressure monitoring, ambulatory
  • Ventricular function, left

ASJC Scopus subject areas

  • Internal Medicine


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