Blood pressure control in resistant hypertension: New therapeutic options

Guido Grassi, Fosca Quarti-Trevano, Gianmaria Brambilla, Gino Seravalle

Research output: Contribution to journalArticlepeer-review


Resistant hypertension, namely the hypertensive state characterized by the inability of multiple antihypertensive drug interventions to lower blood pressure to goal levels, represents a condition frequently detected in clinical practice. Its main features are represented by its heterogeneous etiology as well as its very high cardiovascular risk. This latter peculiarity has implemented the research for new approaches to the treatment of the disease. This article will focus on two of them, namely carotid baroreceptor electric stimulation and the renal denervation procedure. Clinical studies and large-scale clinical trials are presently ongoing with the aim of defining the long-term efficacy and safety profile of the two interventions.

Original languageEnglish
Pages (from-to)1579-1585
Number of pages7
JournalExpert Review of Cardiovascular Therapy
Issue number11
Publication statusPublished - Nov 2010


  • antihypertensive treatment
  • blood pressure control
  • carotid baroreceptor stimulation
  • renal denervation
  • renin-angiotensin system
  • resistant hypertension
  • sympathetic nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine


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