Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

Steffen Weikert; Heiner Boeing; Tobias Pischon; Cornelia Weikert; Anja Olsen; Anne Tjonneland; Kim Overvad; Nikolaus Becker; Jakob Linseisen; Antonia Trichopoulou; Theodore Mountokalakis; Dimitrios Trichopoulos; Sabina Sieri; Domenico Palli; Paolo Vineis; Salvatore Panico; Petra H M Peeters; H. Bas Bueno-De-Mesquita; W. M Monique Verschuren; Borje Ljungberg; Goran Hallmans; Goran Berglund; Carlos A. González; Miren Dorronsoro; Aurelio Barricarte; M. J. Tormo; Naomi Allen; Andrew Roddam; Sheila Bingham; Kay Tee Khaw; Sabina Rinaldi; Pietro Ferrari; Teresa Norat; Elio Riboli

doi:10.1093/aje/kwm321

Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

Steffen Weikert, Heiner Boeing, Tobias Pischon, Cornelia Weikert, Anja Olsen, Anne Tjonneland, Kim Overvad, Nikolaus Becker, Jakob Linseisen, Antonia Trichopoulou, Theodore Mountokalakis, Dimitrios Trichopoulos, Sabina Sieri, Domenico Palli, Paolo Vineis, Salvatore Panico, Petra H M Peeters, H. Bas Bueno-De-Mesquita, W. M Monique Verschuren, Borje LjungbergGoran Hallmans, Goran Berglund, Carlos A. González, Miren Dorronsoro, Aurelio Barricarte, M. J. Tormo, Naomi Allen, Andrew Roddam, Sheila Bingham, Kay Tee Khaw, Sabina Rinaldi, Pietro Ferrari, Teresa Norat, Elio Riboli

Fondazione IRCCS Istituto Nazionale dei Tumori

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Abstract

Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood pressure was measured in 296,638 women and men, recruited in eight European countries during 1992-1998, 254,935 of whom provided information on antihypertensive medication. During a mean follow-up of 6.2 years, 250 cases of RCC were identified. Blood pressure was independently associated with risk of RCC. The relative risks for the highest versus the lowest category of systolic (≥160 mmHg vs.

Original language	English
Pages (from-to)	438-446
Number of pages	9
Journal	American Journal of Epidemiology
Volume	167
Issue number	4
DOIs	https://doi.org/10.1093/aje/kwm321
Publication status	Published - Feb 2008

Keywords

Antihypertensive agents
Hypertension
Kidney neoplasms
Risk factors

ASJC Scopus subject areas

Epidemiology

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10.1093/aje/kwm321

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Weikert, S., Boeing, H., Pischon, T., Weikert, C., Olsen, A., Tjonneland, A., Overvad, K., Becker, N., Linseisen, J., Trichopoulou, A., Mountokalakis, T., Trichopoulos, D., Sieri, S., Palli, D., Vineis, P., Panico, S., Peeters, P. H. M., Bueno-De-Mesquita, H. B., Verschuren, W. M. M., ... Riboli, E. (2008). Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition. American Journal of Epidemiology, 167(4), 438-446. https://doi.org/10.1093/aje/kwm321

Weikert, S, Boeing, H, Pischon, T, Weikert, C, Olsen, A, Tjonneland, A, Overvad, K, Becker, N, Linseisen, J, Trichopoulou, A, Mountokalakis, T, Trichopoulos, D, Sieri, S, Palli, D, Vineis, P, Panico, S, Peeters, PHM, Bueno-De-Mesquita, HB, Verschuren, WMM, Ljungberg, B, Hallmans, G, Berglund, G, González, CA, Dorronsoro, M, Barricarte, A, Tormo, MJ, Allen, N, Roddam, A, Bingham, S, Khaw, KT, Rinaldi, S, Ferrari, P, Norat, T & Riboli, E 2008, 'Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition', American Journal of Epidemiology, vol. 167, no. 4, pp. 438-446. https://doi.org/10.1093/aje/kwm321

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abstract = "Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood pressure was measured in 296,638 women and men, recruited in eight European countries during 1992-1998, 254,935 of whom provided information on antihypertensive medication. During a mean follow-up of 6.2 years, 250 cases of RCC were identified. Blood pressure was independently associated with risk of RCC. The relative risks for the highest versus the lowest category of systolic (≥160 mmHg vs. ",

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AU - Tjonneland, Anne

AU - Overvad, Kim

AU - Becker, Nikolaus

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AU - Trichopoulou, Antonia

AU - Mountokalakis, Theodore

AU - Trichopoulos, Dimitrios

AU - Sieri, Sabina

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AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Peeters, Petra H M

AU - Bueno-De-Mesquita, H. Bas

AU - Verschuren, W. M Monique

AU - Ljungberg, Borje

AU - Hallmans, Goran

AU - Berglund, Goran

AU - González, Carlos A.

AU - Dorronsoro, Miren

AU - Barricarte, Aurelio

AU - Tormo, M. J.

AU - Allen, Naomi

AU - Roddam, Andrew

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Rinaldi, Sabina

AU - Ferrari, Pietro

AU - Norat, Teresa

AU - Riboli, Elio

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Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

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Keywords

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