BKV QPCR detection and infection monitoring in renal transplant recipients

Monica Mischitelli; Daniela Fioriti; Elena Anzivino; Anna Bellizzi; Giancarlo Ferretti; Norberto Gussman; Anna Paola Mitterhofer; Francesca Tinti; Mario Barile; Maurizio Dal Maso; Fernanda Chiarini; Valeria Pietropaolo

BKV QPCR detection and infection monitoring in renal transplant recipients

Monica Mischitelli, Daniela Fioriti, Elena Anzivino, Anna Bellizzi, Giancarlo Ferretti, Norberto Gussman, Anna Paola Mitterhofer, Francesca Tinti, Mario Barile, Maurizio Dal Maso, Fernanda Chiarini, Valeria Pietropaolo

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

BKV associated nephropathy (BKVAN) is a cause of renal dysfunction and loss of the graft in transplants. Viral primary infection is usually inapparent and then BKV establishes latency in kidneys. Reactivation occurs in immunocompromised conditions in renal transplant recipients who can develop a subclinical nephritis and eventually a BKV-associated interstitial nephritis or a BKVAN. In this study, we searched for BKV copies in urine and plasma of renal transplants by quantitative assay (QPCR). Results showed that in several patients clearance of viremia is associated with persistent viruria, suggesting that both specimens are necessary to correctly monitor a BKVAN.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	New Microbiologica
Volume	30
Issue number	3
Publication status	Published - Jul 2007

Keywords

BKV
BKVAN
QPCR
Viremia
Viruria

ASJC Scopus subject areas

Microbiology (medical)
Microbiology

Cite this

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abstract = "BKV associated nephropathy (BKVAN) is a cause of renal dysfunction and loss of the graft in transplants. Viral primary infection is usually inapparent and then BKV establishes latency in kidneys. Reactivation occurs in immunocompromised conditions in renal transplant recipients who can develop a subclinical nephritis and eventually a BKV-associated interstitial nephritis or a BKVAN. In this study, we searched for BKV copies in urine and plasma of renal transplants by quantitative assay (QPCR). Results showed that in several patients clearance of viremia is associated with persistent viruria, suggesting that both specimens are necessary to correctly monitor a BKVAN.",

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AU - Mischitelli, Monica

AU - Fioriti, Daniela

AU - Anzivino, Elena

AU - Bellizzi, Anna

AU - Ferretti, Giancarlo

AU - Gussman, Norberto

AU - Mitterhofer, Anna Paola

AU - Tinti, Francesca

AU - Barile, Mario

AU - Dal Maso, Maurizio

AU - Chiarini, Fernanda

AU - Pietropaolo, Valeria

PY - 2007/7

Y1 - 2007/7

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AB - BKV associated nephropathy (BKVAN) is a cause of renal dysfunction and loss of the graft in transplants. Viral primary infection is usually inapparent and then BKV establishes latency in kidneys. Reactivation occurs in immunocompromised conditions in renal transplant recipients who can develop a subclinical nephritis and eventually a BKV-associated interstitial nephritis or a BKVAN. In this study, we searched for BKV copies in urine and plasma of renal transplants by quantitative assay (QPCR). Results showed that in several patients clearance of viremia is associated with persistent viruria, suggesting that both specimens are necessary to correctly monitor a BKVAN.

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KW - Viruria

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BKV QPCR detection and infection monitoring in renal transplant recipients

Abstract

Keywords

ASJC Scopus subject areas

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