BIT-mapped somatosensory evoked potentials in the fragile X syndrome

R. Ferri, SA Musumeci, M. Elia, S. Del Gracco, C. Scuderi, P. Bergonzi

Research output: Contribution to journalArticlepeer-review


Middle-latency somatosensory evoked potentials (MLSEPs) were recorded from 19 scalp electrodes in ten male patients with the fragile X (fraX) syndrome and nine normal controls. One fraX patient was found presenting the so-called "giant" MLSEPs with an amplitude of N60 of about 60 μV and of 40 μV after stimulation of the right and left median nerves, respectively. Tapping of the right hand, in the same patient, induced the appearance of left parietal evoked EEG spikes. These findings further support the already suggested similarity between the epileptic picture of several fraX patients with that of the benign childhood epilepsy with centrotemporal spikes. Color mapping of the MLSEPs recorded in the remaining nine patients, when compared with the control group, showed an abnormally large N30 over the frontal regions, together with an increase in amplitude of P27, over the parietal areas, and of N60 and P100 which also presented abnormal field distributions, being represented preferentially over the frontal regions. These data could suggest the existence of a cortical dysfunction mostly involving the frontal lobes (supplementary motor area, in particular) in the fraX syndrome which could support many behavioral changes usually observed in these patients.

Original languageEnglish
Pages (from-to)413-426
Number of pages14
JournalNeurophysiologie Clinique / Clinical Neurophysiology
Issue number6
Publication statusPublished - 1994


  • cortical hyperexcitability
  • fragile X syndrome
  • frontal lobe dysfunction
  • middle-latency somatosensory evoked potentials
  • topographic brain mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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