Biosafety of Prions

Edoardo Bistaffa; Edoardo Bistaffa; Martina Rossi; Chiara M.G. De Luca; Chiara M.G. De Luca; Fabio Moda

doi:10.1016/bs.pmbts.2017.06.017

Biosafety of Prions

Edoardo Bistaffa, Edoardo Bistaffa, Martina Rossi, Chiara M.G. De Luca, Chiara M.G. De Luca, Fabio Moda

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

© 2017 Elsevier Inc. Prions are the infectious agents that cause devastating and untreatable disorders known as Transmissible Spongiform Encephalopathies (TSEs). The pathologic events and the infectious nature of these transmissible agents are not completely understood yet. Due to the difficulties in inactivating prions, working with them requires specific recommendations and precautions. Moreover, with the advent of innovative technologies, such as the Protein Misfolding Cyclic Amplification (PMCA) and the Real Time Quaking-Induced Conversion (RT-QuIC), prions could be amplified in vitro and the infectious features of the amplified products need to be carefully assessed.

Original language	English
Title of host publication	Progress in Molecular Biology and Translational Science
Pages	455-485
Number of pages	31
Volume	150
DOIs	https://doi.org/10.1016/bs.pmbts.2017.06.017
Publication status	Published - Jan 1 2017

Keywords

Biosafety
Decontamination
Infectivity
Prion diseases
Transmission

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10.1016/bs.pmbts.2017.06.017

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title = "Biosafety of Prions",

abstract = "{\textcopyright} 2017 Elsevier Inc. Prions are the infectious agents that cause devastating and untreatable disorders known as Transmissible Spongiform Encephalopathies (TSEs). The pathologic events and the infectious nature of these transmissible agents are not completely understood yet. Due to the difficulties in inactivating prions, working with them requires specific recommendations and precautions. Moreover, with the advent of innovative technologies, such as the Protein Misfolding Cyclic Amplification (PMCA) and the Real Time Quaking-Induced Conversion (RT-QuIC), prions could be amplified in vitro and the infectious features of the amplified products need to be carefully assessed.",

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AU - Moda, Fabio

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AB - © 2017 Elsevier Inc. Prions are the infectious agents that cause devastating and untreatable disorders known as Transmissible Spongiform Encephalopathies (TSEs). The pathologic events and the infectious nature of these transmissible agents are not completely understood yet. Due to the difficulties in inactivating prions, working with them requires specific recommendations and precautions. Moreover, with the advent of innovative technologies, such as the Protein Misfolding Cyclic Amplification (PMCA) and the Real Time Quaking-Induced Conversion (RT-QuIC), prions could be amplified in vitro and the infectious features of the amplified products need to be carefully assessed.

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KW - Transmission

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BT - Progress in Molecular Biology and Translational Science

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Biosafety of Prions

Abstract

Keywords

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