Biological predictors of response to radiotherapy in cervical carcinomas

Maria Grazia Daidone; Umberto Ricardi; Silvia Veneroni; Alessandra Faranda; Elvira Benini; Alessandro Urgesi; Gian Luca Sannazzari; Rosella Silvestrini

Biological predictors of response to radiotherapy in cervical carcinomas

Maria Grazia Daidone, Umberto Ricardi, Silvia Veneroni, Alessandra Faranda, Elvira Benini, Alessandro Urgesi, Gian Luca Sannazzari, Rosella Silvestrini

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

On 21 patients with T1b-T3b tumours subjected to external radiotherapy and brachytherapy, the expression of P53 and glutathione S-transferase π [GST-π], immunohistochemically detected, the S-phase cells fraction (³H-thymidine labeling index, TLI) and DNA content evaluated by image analysis were determined on biopsies before and after the first 10 Gy. P53 accumulation was reduced in 60% of P53-overexpressing tumours and not induced in P53-negative tumours, GST-π was induced in about 40% of pretreatment GST-π-negative cases, TLI was reduced in 70% of the cases regardless of pretreatment values, and DNA profiles remained unchanged in two-thirds of the cases. P53 accumulation was a predictor of 3-year relapse-free survival after radiotherapy, followed by GST-π expression, whereas TLI did not influence prognosis.

Original language	English
Pages (from-to)	41-46
Number of pages	6
Journal	International Journal of Oncology
Volume	10
Issue number	1
Publication status	Published - Jan 1997

Keywords

Cell proliferation
Cervical carcinoma
DNA ploidy
GST-π expression
P53 expression
Radiotherapy

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

@article{ae3dd1a3e96840b4bd49569895a563e5,

title = "Biological predictors of response to radiotherapy in cervical carcinomas",

abstract = "On 21 patients with T1b-T3b tumours subjected to external radiotherapy and brachytherapy, the expression of P53 and glutathione S-transferase π [GST-π], immunohistochemically detected, the S-phase cells fraction (3H-thymidine labeling index, TLI) and DNA content evaluated by image analysis were determined on biopsies before and after the first 10 Gy. P53 accumulation was reduced in 60% of P53-overexpressing tumours and not induced in P53-negative tumours, GST-π was induced in about 40% of pretreatment GST-π-negative cases, TLI was reduced in 70% of the cases regardless of pretreatment values, and DNA profiles remained unchanged in two-thirds of the cases. P53 accumulation was a predictor of 3-year relapse-free survival after radiotherapy, followed by GST-π expression, whereas TLI did not influence prognosis.",

keywords = "Cell proliferation, Cervical carcinoma, DNA ploidy, GST-π expression, P53 expression, Radiotherapy",

author = "Daidone, {Maria Grazia} and Umberto Ricardi and Silvia Veneroni and Alessandra Faranda and Elvira Benini and Alessandro Urgesi and Sannazzari, {Gian Luca} and Rosella Silvestrini",

year = "1997",

month = jan,

language = "English",

volume = "10",

pages = "41--46",

journal = "International Journal of Oncology",

issn = "1019-6439",

publisher = "Spandidos Publications",

number = "1",

}

TY - JOUR

T1 - Biological predictors of response to radiotherapy in cervical carcinomas

AU - Daidone, Maria Grazia

AU - Ricardi, Umberto

AU - Veneroni, Silvia

AU - Faranda, Alessandra

AU - Benini, Elvira

AU - Urgesi, Alessandro

AU - Sannazzari, Gian Luca

AU - Silvestrini, Rosella

PY - 1997/1

Y1 - 1997/1

N2 - On 21 patients with T1b-T3b tumours subjected to external radiotherapy and brachytherapy, the expression of P53 and glutathione S-transferase π [GST-π], immunohistochemically detected, the S-phase cells fraction (3H-thymidine labeling index, TLI) and DNA content evaluated by image analysis were determined on biopsies before and after the first 10 Gy. P53 accumulation was reduced in 60% of P53-overexpressing tumours and not induced in P53-negative tumours, GST-π was induced in about 40% of pretreatment GST-π-negative cases, TLI was reduced in 70% of the cases regardless of pretreatment values, and DNA profiles remained unchanged in two-thirds of the cases. P53 accumulation was a predictor of 3-year relapse-free survival after radiotherapy, followed by GST-π expression, whereas TLI did not influence prognosis.

AB - On 21 patients with T1b-T3b tumours subjected to external radiotherapy and brachytherapy, the expression of P53 and glutathione S-transferase π [GST-π], immunohistochemically detected, the S-phase cells fraction (3H-thymidine labeling index, TLI) and DNA content evaluated by image analysis were determined on biopsies before and after the first 10 Gy. P53 accumulation was reduced in 60% of P53-overexpressing tumours and not induced in P53-negative tumours, GST-π was induced in about 40% of pretreatment GST-π-negative cases, TLI was reduced in 70% of the cases regardless of pretreatment values, and DNA profiles remained unchanged in two-thirds of the cases. P53 accumulation was a predictor of 3-year relapse-free survival after radiotherapy, followed by GST-π expression, whereas TLI did not influence prognosis.

KW - Cell proliferation

KW - Cervical carcinoma

KW - DNA ploidy

KW - GST-π expression

KW - P53 expression

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=0031024559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031024559&partnerID=8YFLogxK

M3 - Article

C2 - 21533341

AN - SCOPUS:0031024559

SN - 1019-6439

VL - 10

SP - 41

EP - 46

JO - International Journal of Oncology

JF - International Journal of Oncology

IS - 1

ER -

Biological predictors of response to radiotherapy in cervical carcinomas

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this