Biological features of the clone involved in primary amyloidosis (AL)

V. Perfetti, M. Colli Vignarelli, S. Casarini, E. Ascari, G. Merlini

Research output: Contribution to journalArticlepeer-review


Primary light chain-associated amyloidosis (AL) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). It is the most common form of systemic amyloidosis in Western countries and is rapidly fatal. Knowledge of the pathobiology of the underlying B cell clone is of primary importance for the design and optimization of therapeutic strategies.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
Issue number2
Publication statusPublished - 2001


  • AL amyloidosis
  • B cell lymphoproliferative disorders
  • Plasma cell dyscrasias
  • Primary amyloidosis

ASJC Scopus subject areas

  • Hematology
  • Cancer Research


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