Biological features of the clone involved in primary amyloidosis (AL)

V. Perfetti; M. Colli Vignarelli; S. Casarini; E. Ascari; G. Merlini

doi:10.1038/sj.leu.2402015

Biological features of the clone involved in primary amyloidosis (AL)

V. Perfetti, M. Colli Vignarelli, S. Casarini, E. Ascari, G. Merlini

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Primary light chain-associated amyloidosis (AL) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). It is the most common form of systemic amyloidosis in Western countries and is rapidly fatal. Knowledge of the pathobiology of the underlying B cell clone is of primary importance for the design and optimization of therapeutic strategies.

Original language	English
Pages (from-to)	195-202
Number of pages	8
Journal	Leukemia
Volume	15
Issue number	2
DOIs	https://doi.org/10.1038/sj.leu.2402015
Publication status	Published - 2001

Keywords

AL amyloidosis
B cell lymphoproliferative disorders
Plasma cell dyscrasias
Primary amyloidosis

ASJC Scopus subject areas

Hematology
Cancer Research

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10.1038/sj.leu.2402015

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AU - Merlini, G.

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KW - B cell lymphoproliferative disorders

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Biological features of the clone involved in primary amyloidosis (AL)

Abstract

Keywords

ASJC Scopus subject areas

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