Biological characterization of central and peripheral primary Non Small Cell Lung Cancers (NSCLC)

Natalia Maria Malara, Alessandro Sgambato, Pierluigi Granone, Giovanna Flamini, Stefano Margaritora, Alma Boninsegna, Alfredo Cesario, Domenico Galetta, Qing Yang, Achille Cittadini

Research output: Contribution to journalArticlepeer-review


Background: Non Small Cell Lung Carcinomas (NSCLC) compise 90% of all lung carcinomas. Studies have demonstrated a preferential central (bronchus-derived) localization for squamous cells, whereas adenocarcinomas are frequently peripheral (bronchiolo-alveolus derived). It has been suggested that exposure to carcinogenic insults including cigarette smoke, may induce different types of tumors in different locations. Materials and Methods: Forty one NSCLC patients staged according to WHO and TNM were considered for localization and biological parameters (p53 expression, cell ploidy and S-phase). Results: p53 overexpression was found more frequently in central than in peripheral tumors (69% vs 39%) (p = 0.074). Central tumors were more aneuploid (69%) than peripheral ones (46%) (p = 0.03). No difference in smoking habit was observed in the two groups. Conclusions: Our results suggest that there is no apparent biological difference between these two groups of NSCLCs, and that the smoking does not play a role in either histotype determination or biological behaviour.

Original languageEnglish
Pages (from-to)2249-2252
Number of pages4
JournalAnticancer Research
Issue number3 B
Publication statusPublished - 1999


  • Central
  • p53
  • Peripheral
  • S phase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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