Biofluids profile of α-Klotho in patients with Parkinson's disease

Giulia Maria Sancesario, Giulia Di Lazzaro, Piergiorgio Grillo, Benedetta Biticchi, Emilia Giannella, Mohammad Alwardat, Massimo Pieri, Sergio Bernardini, Nicola Biagio Mercuri, Antonio Pisani, Tommaso Schirinzi

Research output: Contribution to journalArticlepeer-review


We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.

Original languageEnglish
Pages (from-to)62-64
Number of pages3
JournalParkinsonism and Related Disorders
Publication statusE-pub ahead of print - Aug 10 2021


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