Biofluids profile of α-Klotho in patients with Parkinson's disease

Giulia Maria Sancesario; Giulia Di Lazzaro; Piergiorgio Grillo; Benedetta Biticchi; Emilia Giannella; Mohammad Alwardat; Massimo Pieri; Sergio Bernardini; Nicola Biagio Mercuri; Antonio Pisani; Tommaso Schirinzi

doi:10.1016/j.parkreldis.2021.08.004

Biofluids profile of α-Klotho in patients with Parkinson's disease

Giulia Maria Sancesario, Giulia Di Lazzaro, Piergiorgio Grillo, Benedetta Biticchi, Emilia Giannella, Mohammad Alwardat, Massimo Pieri, Sergio Bernardini, Nicola Biagio Mercuri, Antonio Pisani, Tommaso Schirinzi

Research output: Contribution to journal › Article › peer-review

Abstract

We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.

Original language	English
Pages (from-to)	62-64
Number of pages	3
Journal	Parkinsonism and Related Disorders
Volume	90
DOIs	https://doi.org/10.1016/j.parkreldis.2021.08.004
Publication status	E-pub ahead of print - Aug 10 2021

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10.1016/j.parkreldis.2021.08.004

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title = "Biofluids profile of α-Klotho in patients with Parkinson's disease",

abstract = "We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.",

author = "Sancesario, {Giulia Maria} and {Di Lazzaro}, Giulia and Piergiorgio Grillo and Benedetta Biticchi and Emilia Giannella and Mohammad Alwardat and Massimo Pieri and Sergio Bernardini and Mercuri, {Nicola Biagio} and Antonio Pisani and Tommaso Schirinzi",

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doi = "10.1016/j.parkreldis.2021.08.004",

language = "English",

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journal = "Parkinsonism and Related Disorders",

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TY - JOUR

T1 - Biofluids profile of α-Klotho in patients with Parkinson's disease

AU - Sancesario, Giulia Maria

AU - Di Lazzaro, Giulia

AU - Grillo, Piergiorgio

AU - Biticchi, Benedetta

AU - Giannella, Emilia

AU - Alwardat, Mohammad

AU - Pieri, Massimo

AU - Bernardini, Sergio

AU - Mercuri, Nicola Biagio

AU - Pisani, Antonio

AU - Schirinzi, Tommaso

PY - 2021/8/10

Y1 - 2021/8/10

N2 - We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.

AB - We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.

U2 - 10.1016/j.parkreldis.2021.08.004

DO - 10.1016/j.parkreldis.2021.08.004

M3 - Article

C2 - 34392132

SN - 1353-8020

VL - 90

SP - 62

EP - 64

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

ER -

Biofluids profile of α-Klotho in patients with Parkinson's disease

Abstract

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