TY - JOUR
T1 - Biocompatible nanocomposite for PET/MRI hybrid imaging
AU - Locatelli, Erica
AU - Gil, Larraitz
AU - Israel, Liron Limor
AU - Passoni, Lorena
AU - Naddaka, Maria
AU - Pucci, Andrea
AU - Reese, Torsten
AU - Gomez-Vallejo, Vanessa
AU - Milani, Paolo
AU - Matteoli, Michela
AU - Llop, Jordi
AU - Lellouche, Jean Paul
AU - Comes Franchini, Mauro
PY - 2012
Y1 - 2012
N2 - A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2'-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.
AB - A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2'-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.
KW - Maghemite nanoparticles
KW - Magnetic resonance imaging
KW - Organic coating
KW - Polymeric nanoparticles
KW - Positron emission tomography
KW - Radiolabeling
UR - http://www.scopus.com/inward/record.url?scp=84875835851&partnerID=8YFLogxK
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U2 - 10.2147/IJN.S38107
DO - 10.2147/IJN.S38107
M3 - Article
C2 - 23271907
AN - SCOPUS:84875835851
SN - 1176-9114
VL - 7
SP - 6021
EP - 6033
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
ER -