Biochemical pharmacology of the anorectic drug fenfluramine: A review

S. Garattini, S. Cactia, T. Mennini, R. Samanin, S. Consolo, H. Ladinsky

Research output: Contribution to journalArticlepeer-review


Recent data on the distribution and metabolism of dl-fenfluramine are reviewed and a probable mechanism of action by which this compound induces a decrease in food intake is discussed. The results of work carried out mainly in rats under different experimental conditions indicate that the d- and l-isomers of fenfluramine are metabolized in different ways. Furthermore, the two isomers show differentpharmacological andneuro-chemical activity. The contribution of the principal metabolites, d-andl-norfenfiuramine, to the various effects of fenfluramine is discussed.

Original languageEnglish
Pages (from-to)15-27
Number of pages13
JournalCurrent Medical Research and Opinion
Issue numberS1
Publication statusPublished - 1979


  • Appetite Depressants
  • Fenfluramine
  • Pharmacology

ASJC Scopus subject areas

  • Medicine(all)


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