Biochemical pharmacology of the anorectic drug fenfluramine: A review

S. Garattini; S. Cactia; T. Mennini; R. Samanin; S. Consolo; H. Ladinsky

doi:10.1185/03007997909117488

Biochemical pharmacology of the anorectic drug fenfluramine: A review

S. Garattini, S. Cactia, T. Mennini, R. Samanin, S. Consolo, H. Ladinsky

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Recent data on the distribution and metabolism of dl-fenfluramine are reviewed and a probable mechanism of action by which this compound induces a decrease in food intake is discussed. The results of work carried out mainly in rats under different experimental conditions indicate that the d- and l-isomers of fenfluramine are metabolized in different ways. Furthermore, the two isomers show differentpharmacological andneuro-chemical activity. The contribution of the principal metabolites, d-andl-norfenfiuramine, to the various effects of fenfluramine is discussed.

Original language	English
Pages (from-to)	15-27
Number of pages	13
Journal	Current Medical Research and Opinion
Volume	6
Issue number	S1
DOIs	https://doi.org/10.1185/03007997909117488
Publication status	Published - 1979

Keywords

Appetite Depressants
Fenfluramine
Pharmacology

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1185/03007997909117488

Cite this

@article{55ce8daef3c543f6a748ba7233abdba2,

title = "Biochemical pharmacology of the anorectic drug fenfluramine: A review",

abstract = "Recent data on the distribution and metabolism of dl-fenfluramine are reviewed and a probable mechanism of action by which this compound induces a decrease in food intake is discussed. The results of work carried out mainly in rats under different experimental conditions indicate that the d- and l-isomers of fenfluramine are metabolized in different ways. Furthermore, the two isomers show differentpharmacological andneuro-chemical activity. The contribution of the principal metabolites, d-andl-norfenfiuramine, to the various effects of fenfluramine is discussed.",

keywords = "Appetite Depressants, Fenfluramine, Pharmacology",

author = "S. Garattini and S. Cactia and T. Mennini and R. Samanin and S. Consolo and H. Ladinsky",

year = "1979",

doi = "10.1185/03007997909117488",

language = "English",

volume = "6",

pages = "15--27",

journal = "Current Medical Research and Opinion",

issn = "0300-7995",

publisher = "Informa Healthcare",

number = "S1",

}

TY - JOUR

T1 - Biochemical pharmacology of the anorectic drug fenfluramine

T2 - A review

AU - Garattini, S.

AU - Cactia, S.

AU - Mennini, T.

AU - Samanin, R.

AU - Consolo, S.

AU - Ladinsky, H.

PY - 1979

Y1 - 1979

N2 - Recent data on the distribution and metabolism of dl-fenfluramine are reviewed and a probable mechanism of action by which this compound induces a decrease in food intake is discussed. The results of work carried out mainly in rats under different experimental conditions indicate that the d- and l-isomers of fenfluramine are metabolized in different ways. Furthermore, the two isomers show differentpharmacological andneuro-chemical activity. The contribution of the principal metabolites, d-andl-norfenfiuramine, to the various effects of fenfluramine is discussed.

AB - Recent data on the distribution and metabolism of dl-fenfluramine are reviewed and a probable mechanism of action by which this compound induces a decrease in food intake is discussed. The results of work carried out mainly in rats under different experimental conditions indicate that the d- and l-isomers of fenfluramine are metabolized in different ways. Furthermore, the two isomers show differentpharmacological andneuro-chemical activity. The contribution of the principal metabolites, d-andl-norfenfiuramine, to the various effects of fenfluramine is discussed.

KW - Appetite Depressants

KW - Fenfluramine

KW - Pharmacology

UR - http://www.scopus.com/inward/record.url?scp=0018761950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018761950&partnerID=8YFLogxK

U2 - 10.1185/03007997909117488

DO - 10.1185/03007997909117488

M3 - Article

AN - SCOPUS:0018761950

SN - 0300-7995

VL - 6

SP - 15

EP - 27

JO - Current Medical Research and Opinion

JF - Current Medical Research and Opinion

IS - S1

ER -

Biochemical pharmacology of the anorectic drug fenfluramine: A review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this