Biochemical markers in early diagnosis and management of systemic amyloidoses

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Systemic amyloid diseases are characterized by widespread protein deposition as amyloid fibrils. Precise diagnostic framing is the prerequisite for a correct management of patients. This complex process is achieved through a series of steps, which include detection of the tissue amyloid deposits, identification of the amyloid type, demonstration of the amyloidogenic precursor, and evaluation of organ dysfunction/damage. Laboratory medicine plays a central role in the diagnosis and management of systemic amyloidoses, through the quantification of the amyloidogenic precursor and evaluation of end-organ damage using biomarkers.

Original languageEnglish
Pages (from-to)1517-1531
Number of pages15
JournalClinical Chemistry and Laboratory Medicine
Issue number11
Publication statusPublished - Nov 19 2014


  • amyloidosis
  • biomarkers
  • early diagnosis
  • monoclonal gammopathies

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)


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