TY - JOUR
T1 - Biochemical markers in early diagnosis and management of systemic amyloidoses
AU - Lavatelli, Francesca
AU - Albertini, Riccardo
AU - Di Fonzo, Andrea
AU - Palladini, Giovanni
AU - Merlini, Giampaolo
PY - 2014/11/19
Y1 - 2014/11/19
N2 - Systemic amyloid diseases are characterized by widespread protein deposition as amyloid fibrils. Precise diagnostic framing is the prerequisite for a correct management of patients. This complex process is achieved through a series of steps, which include detection of the tissue amyloid deposits, identification of the amyloid type, demonstration of the amyloidogenic precursor, and evaluation of organ dysfunction/damage. Laboratory medicine plays a central role in the diagnosis and management of systemic amyloidoses, through the quantification of the amyloidogenic precursor and evaluation of end-organ damage using biomarkers.
AB - Systemic amyloid diseases are characterized by widespread protein deposition as amyloid fibrils. Precise diagnostic framing is the prerequisite for a correct management of patients. This complex process is achieved through a series of steps, which include detection of the tissue amyloid deposits, identification of the amyloid type, demonstration of the amyloidogenic precursor, and evaluation of organ dysfunction/damage. Laboratory medicine plays a central role in the diagnosis and management of systemic amyloidoses, through the quantification of the amyloidogenic precursor and evaluation of end-organ damage using biomarkers.
KW - amyloidosis
KW - biomarkers
KW - early diagnosis
KW - monoclonal gammopathies
UR - http://www.scopus.com/inward/record.url?scp=84908093884&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908093884&partnerID=8YFLogxK
U2 - 10.1515/cclm-2014-0235
DO - 10.1515/cclm-2014-0235
M3 - Article
C2 - 24870609
AN - SCOPUS:84908093884
SN - 1434-6621
VL - 52
SP - 1517
EP - 1531
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 11
ER -