TY - JOUR
T1 - Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease)
AU - Vergani, Carlo G.
AU - Plancher, Angello C.
AU - Zuin, Massimo
AU - Cattaneo, Marco
AU - Tramaloni, Casimiro
AU - Maccari, Sergio
AU - Roma, Paola
AU - Catapano, Alberico L.
PY - 1984
Y1 - 1984
N2 - A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B 2. A platelet storage pool deficiency was also found.
AB - A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B 2. A platelet storage pool deficiency was also found.
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M3 - Article
C2 - 6421598
AN - SCOPUS:0021361391
SN - 0014-2972
VL - 14
SP - 49
EP - 54
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
IS - 1
ER -