TY - JOUR
T1 - Benzodiazepine receptor binding in Huntington's disease
T2 - [11C]flumazenil uptake measured using positron emission tomography
AU - Künig, Gabriella
AU - Leenders, Klaus L.
AU - Sanchez-Pernaute, Rosario
AU - Antonini, Angelo
AU - Vontobel, Peter
AU - Verhagen, Aalt
AU - Günther, Ilonka
PY - 2000
Y1 - 2000
N2 - We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation.
AB - We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation.
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U2 - 10.1002/1531-8249(200005)47:5<644::AID-ANA13>3.0.CO;2-C
DO - 10.1002/1531-8249(200005)47:5<644::AID-ANA13>3.0.CO;2-C
M3 - Article
C2 - 10805336
AN - SCOPUS:0342264568
SN - 0364-5134
VL - 47
SP - 644
EP - 648
JO - Annals of Neurology
JF - Annals of Neurology
IS - 5
ER -