TY - JOUR
T1 - Basilar and Middle Cerebral Artery Reactivity in Patients with Migraine
AU - Silvestrini, Mauro
AU - Baruffaldi, Roberto
AU - Bartolini, Marco
AU - Vernieri, Fabrizio
AU - Lanciotti, Chiara
AU - Matteis, Maria
AU - Troisi, Elio
AU - Provinciali, Leandro
PY - 2004/1
Y1 - 2004/1
N2 - Background.-Migraine has been reported as a possible risk factor for ischemic stroke. The mechanisms underlying this association are unknown. Objective.-To evaluate cerebrovascular reactivity to hypercapnia in the anterior and posterior circulation of patients with migraine, as reduced cerebrovascular reactivity is associated with a predisposition to stroke in various clinical conditions. Methods.-Using transcranial Doppler ultrasonography, changes in flow velocity during apnea were measured in both middle cerebral arteries and in the basilar artery of 15 control subjects and 30 patients with migraine (15 with aura and 15 without aura) during an attack-free period. Cerebrovascular reactivity was evaluated using the breath-holding index, which is calculated by dividing the percent increase in mean flow velocity recorded during a breath-holding episode by its duration (in seconds) after a normal inspiration. Results.-Vascular reactivity in the middle cerebral arteries was similar in patients and controls and significantly lower in the basilar artery of patients with migraine with aura compared with the other 2 groups (P
AB - Background.-Migraine has been reported as a possible risk factor for ischemic stroke. The mechanisms underlying this association are unknown. Objective.-To evaluate cerebrovascular reactivity to hypercapnia in the anterior and posterior circulation of patients with migraine, as reduced cerebrovascular reactivity is associated with a predisposition to stroke in various clinical conditions. Methods.-Using transcranial Doppler ultrasonography, changes in flow velocity during apnea were measured in both middle cerebral arteries and in the basilar artery of 15 control subjects and 30 patients with migraine (15 with aura and 15 without aura) during an attack-free period. Cerebrovascular reactivity was evaluated using the breath-holding index, which is calculated by dividing the percent increase in mean flow velocity recorded during a breath-holding episode by its duration (in seconds) after a normal inspiration. Results.-Vascular reactivity in the middle cerebral arteries was similar in patients and controls and significantly lower in the basilar artery of patients with migraine with aura compared with the other 2 groups (P
KW - Cerebrovascular reactivity
KW - Migraine
KW - Stroke risk factors
KW - Transcranial Doppler ultrasonography
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U2 - 10.1111/j.1526-4610.2004.04006.x
DO - 10.1111/j.1526-4610.2004.04006.x
M3 - Article
C2 - 14979880
AN - SCOPUS:1642527484
SN - 0017-8748
VL - 44
SP - 29
EP - 34
JO - Headache
JF - Headache
IS - 1
ER -