Bacterial toxins and the Rho GTP-binding protein: What microbes teach us about cell regulation

Carla Florentini; Michel Gauthier; Gianfranco Donelli; Patrice Boquet

Bacterial toxins and the Rho GTP-binding protein: What microbes teach us about cell regulation

Carla Florentini, Michel Gauthier, Gianfranco Donelli, Patrice Boquet

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

Original language	English
Pages (from-to)	720-728
Number of pages	9
Journal	Cell Death and Differentiation
Volume	5
Issue number	9
Publication status	Published - Sept 1998

Keywords

C3
Cell regulation
CNF1
Rho

ASJC Scopus subject areas

Cell Biology

Cite this

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abstract = "In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.",

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AU - Boquet, Patrice

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AB - In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

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ER -

Bacterial toxins and the Rho GTP-binding protein: What microbes teach us about cell regulation

Abstract

Keywords

ASJC Scopus subject areas

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