B-cell development: A comparison between mouse and man

Paolo Ghia; Edwin Ten Boekel; Antonius G. Rolink; Fritz Melchers

doi:10.1016/S0167-5699(98)01330-9

B-cell development: A comparison between mouse and man

Paolo Ghia, Edwin Ten Boekel, Antonius G. Rolink, Fritz Melchers

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component λ5/14.1, shows a similar phenotype of B-cell deficiency as the λ5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.

Original language	English
Pages (from-to)	480-485
Number of pages	6
Journal	Immunology Today
Volume	19
Issue number	10
DOIs	https://doi.org/10.1016/S0167-5699(98)01330-9
Publication status	Published - Oct 1998

ASJC Scopus subject areas

Immunology

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10.1016/S0167-5699(98)01330-9

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title = "B-cell development: A comparison between mouse and man",

abstract = "A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component λ5/14.1, shows a similar phenotype of B-cell deficiency as the λ5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.",

author = "Paolo Ghia and {Ten Boekel}, Edwin and Rolink, {Antonius G.} and Fritz Melchers",

year = "1998",

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AU - Ghia, Paolo

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AU - Rolink, Antonius G.

AU - Melchers, Fritz

PY - 1998/10

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AB - A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component λ5/14.1, shows a similar phenotype of B-cell deficiency as the λ5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.

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B-cell development: A comparison between mouse and man

Abstract

ASJC Scopus subject areas

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