A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component λ5/14.1, shows a similar phenotype of B-cell deficiency as the λ5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.
|Number of pages||6|
|Publication status||Published - Oct 1998|
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