B-cell development: A comparison between mouse and man

Paolo Ghia, Edwin Ten Boekel, Antonius G. Rolink, Fritz Melchers

Research output: Contribution to journalArticlepeer-review


A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component λ5/14.1, shows a similar phenotype of B-cell deficiency as the λ5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.

Original languageEnglish
Pages (from-to)480-485
Number of pages6
JournalImmunology Today
Issue number10
Publication statusPublished - Oct 1998

ASJC Scopus subject areas

  • Immunology


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