Azithromycin and lower respiratory tract infections

Francesco Blasi, M. Cazzola, P. Tarsia, R. Cosentini, S. Aliberti, P. Santus, L. Allergra

Research output: Contribution to journalArticlepeer-review


Azithromycin is a macrolide antibiotic that has been structurally modified from erythromycin with an expanded spectrum of activity and improved tissue pharmacokinetic characteristics relative to erythromycin. This allows once-daily administration for 3-5 days of treatment compared with traditional multi dosing 7-10-day treatment regimens. It has been successfully employed in lower respiratory tract infections. Recent data indicate that azithromycin may exert anti-inflammatory/immunomodulatory effects that may be of use in the treatment of both acute and chronic airway diseases. This review examines the role of azithromycin in lower respiratory tract infections analysing published data on exacerbations of chronic bronchitis, community-acquired pneumonia and cystic fibrosis both in adults and children. In addition, pharmacokinetic and pharmacodynamic properties of the drug are also considered.

Original languageEnglish
Pages (from-to)2335-2351
Number of pages17
JournalExpert Opinion on Pharmacotherapy
Issue number13
Publication statusPublished - Oct 2005


  • Anti-inflammatory effects
  • Azithromycin
  • Lower respiratory tract infections

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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