Autonomic nervous system and microcirculation in diabetes

Marco Rossi; Luigi Ricordi; Emilio Mevio; Gabriele Fornasari; Cesare Orlandi; Pietro Fratino; Giorgio Finardi; Luciano Bernardi

doi:10.1016/0165-1838(90)90117-2

Autonomic nervous system and microcirculation in diabetes

Marco Rossi, Luigi Ricordi, Emilio Mevio, Gabriele Fornasari, Cesare Orlandi, Pietro Fratino, Giorgio Finardi, Luciano Bernardi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

In order to evaluate the occurrence of sympathetic impairment of skin microvascular control in diabetes, we evaluated the spectral analysis of forearm skin laser-Doppler fluctuations in nine insulin-dependent diabetic subjects and in 21 controls of similar age. Low-frequency oscillations (around 0.1 Hz) were significantly lower in diabetics than in controls (2.333 ± 0.340 (mean ± SEM) units vs. 3.486 ± 0.093 units, P <0.001), whereas no significant differences were found between the two groups regarding high-frequency respiration-related oscillations. These results suggest that the loss of rhythmicity in diabetic subjects is selectively related to low-frequency oscillations, mostly under sympathetic control, and is likely to be dependent on autonomic abnormality.

Original language	English
Journal	Journal of the Autonomic Nervous System
Volume	30
Issue number	SUPPL.
DOIs	https://doi.org/10.1016/0165-1838(90)90117-2
Publication status	Published - 1990

Keywords

Autonomic nervous system
Diabetes mellitus
Laser-Doppler flowmetry
Skin microcirculation
Spectral analysis

ASJC Scopus subject areas

Physiology
Clinical Neurology
Neuroscience(all)

Access to Document

10.1016/0165-1838(90)90117-2

Cite this

@article{cb35c9718ce84047ad8a202e00ff3c23,

title = "Autonomic nervous system and microcirculation in diabetes",

abstract = "In order to evaluate the occurrence of sympathetic impairment of skin microvascular control in diabetes, we evaluated the spectral analysis of forearm skin laser-Doppler fluctuations in nine insulin-dependent diabetic subjects and in 21 controls of similar age. Low-frequency oscillations (around 0.1 Hz) were significantly lower in diabetics than in controls (2.333 ± 0.340 (mean ± SEM) units vs. 3.486 ± 0.093 units, P <0.001), whereas no significant differences were found between the two groups regarding high-frequency respiration-related oscillations. These results suggest that the loss of rhythmicity in diabetic subjects is selectively related to low-frequency oscillations, mostly under sympathetic control, and is likely to be dependent on autonomic abnormality.",

keywords = "Autonomic nervous system, Diabetes mellitus, Laser-Doppler flowmetry, Skin microcirculation, Spectral analysis",

author = "Marco Rossi and Luigi Ricordi and Emilio Mevio and Gabriele Fornasari and Cesare Orlandi and Pietro Fratino and Giorgio Finardi and Luciano Bernardi",

year = "1990",

doi = "10.1016/0165-1838(90)90117-2",

language = "English",

volume = "30",

journal = "Journal of the Autonomic Nervous System",

issn = "0165-1838",

publisher = "Elsevier BV",

number = "SUPPL.",

}

TY - JOUR

T1 - Autonomic nervous system and microcirculation in diabetes

AU - Rossi, Marco

AU - Ricordi, Luigi

AU - Mevio, Emilio

AU - Fornasari, Gabriele

AU - Orlandi, Cesare

AU - Fratino, Pietro

AU - Finardi, Giorgio

AU - Bernardi, Luciano

PY - 1990

Y1 - 1990

N2 - In order to evaluate the occurrence of sympathetic impairment of skin microvascular control in diabetes, we evaluated the spectral analysis of forearm skin laser-Doppler fluctuations in nine insulin-dependent diabetic subjects and in 21 controls of similar age. Low-frequency oscillations (around 0.1 Hz) were significantly lower in diabetics than in controls (2.333 ± 0.340 (mean ± SEM) units vs. 3.486 ± 0.093 units, P <0.001), whereas no significant differences were found between the two groups regarding high-frequency respiration-related oscillations. These results suggest that the loss of rhythmicity in diabetic subjects is selectively related to low-frequency oscillations, mostly under sympathetic control, and is likely to be dependent on autonomic abnormality.

AB - In order to evaluate the occurrence of sympathetic impairment of skin microvascular control in diabetes, we evaluated the spectral analysis of forearm skin laser-Doppler fluctuations in nine insulin-dependent diabetic subjects and in 21 controls of similar age. Low-frequency oscillations (around 0.1 Hz) were significantly lower in diabetics than in controls (2.333 ± 0.340 (mean ± SEM) units vs. 3.486 ± 0.093 units, P <0.001), whereas no significant differences were found between the two groups regarding high-frequency respiration-related oscillations. These results suggest that the loss of rhythmicity in diabetic subjects is selectively related to low-frequency oscillations, mostly under sympathetic control, and is likely to be dependent on autonomic abnormality.

KW - Autonomic nervous system

KW - Diabetes mellitus

KW - Laser-Doppler flowmetry

KW - Skin microcirculation

KW - Spectral analysis

UR - http://www.scopus.com/inward/record.url?scp=0025105695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025105695&partnerID=8YFLogxK

U2 - 10.1016/0165-1838(90)90117-2

DO - 10.1016/0165-1838(90)90117-2

M3 - Article

C2 - 2212475

AN - SCOPUS:0025105695

SN - 0165-1838

VL - 30

JO - Journal of the Autonomic Nervous System

JF - Journal of the Autonomic Nervous System

IS - SUPPL.

ER -

Autonomic nervous system and microcirculation in diabetes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this