Autonomic nervous system and microcirculation in diabetes

Marco Rossi, Luigi Ricordi, Emilio Mevio, Gabriele Fornasari, Cesare Orlandi, Pietro Fratino, Giorgio Finardi, Luciano Bernardi

Research output: Contribution to journalArticlepeer-review


In order to evaluate the occurrence of sympathetic impairment of skin microvascular control in diabetes, we evaluated the spectral analysis of forearm skin laser-Doppler fluctuations in nine insulin-dependent diabetic subjects and in 21 controls of similar age. Low-frequency oscillations (around 0.1 Hz) were significantly lower in diabetics than in controls (2.333 ± 0.340 (mean ± SEM) units vs. 3.486 ± 0.093 units, P <0.001), whereas no significant differences were found between the two groups regarding high-frequency respiration-related oscillations. These results suggest that the loss of rhythmicity in diabetic subjects is selectively related to low-frequency oscillations, mostly under sympathetic control, and is likely to be dependent on autonomic abnormality.

Original languageEnglish
JournalJournal of the Autonomic Nervous System
Issue numberSUPPL.
Publication statusPublished - 1990


  • Autonomic nervous system
  • Diabetes mellitus
  • Laser-Doppler flowmetry
  • Skin microcirculation
  • Spectral analysis

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)


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