Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis

Giovanni Luigi Mancardi, Alessandra Murialdo, Paolo Rossi, Francesca Gualandi, Gianvito Martino, Alberto Marmont, Fabio Ciceri, Angelo Schenone, Roberto Carlo Parodi, Elisabetta Capello, Giancarlo Comi, Antonio Uccelli

Research output: Contribution to journalArticlepeer-review


Malignant forms of multiple sclerosis (MS) represent a limited group of very aggressive demyelinating diseases, which rapidly progress to severe disability leading often to life-threatening conditions. On these clinical entities, currently available therapies for MS are not very effective. Recently, it has been demonstrated that intense immunosuppression followed by autologous stem cell transplantation (ASC7) can affect the clinical course of individuals with severe MS and completely abrogate the inflammatory activity detected by magnetic resonance imaging (MRI). We report on the treatment with intense immune ablation followed by ASCT of three patients with malignant MS whose clinical course indicated a dramatically poor prognosis. This procedure succeeded in halting the rapidly worsening course of disease. The effect was long lasting, as demonstrated by a sustained efficacy over a two-year period in two subjects and 12 months in the third case. In addition, a striking effect on inflammation-related MRI findings was obtained. These results support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving malignant MS cases unresponsive to conventional therapies.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalMultiple Sclerosis Journal
Issue number3
Publication statusPublished - Jun 2005


  • Autologous stem cells transplantation
  • Immunosuppression
  • MS

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis'. Together they form a unique fingerprint.

Cite this