Autologous bone marrow transplantation for adult advanced stage lymphoblastic lymphoma in first CR. A study of the NHLCSG

G. Santini; A. M. Congiu; P. Coser; T. Chisesi; A. Porcellini; R. Sertoli; A. Contu; O. Vinante; D. Pierluigi; V. Vitale; A. Rubagotti; P. Orcamo; V. Rizzoli

Autologous bone marrow transplantation for adult advanced stage lymphoblastic lymphoma in first CR. A study of the NHLCSG

G. Santini, A. M. Congiu, P. Coser, T. Chisesi, A. Porcellini, R. Sertoli, A. Contu, O. Vinante, D. Pierluigi, V. Vitale, A. Rubagotti, P. Orcamo, V. Rizzoli

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Fourty successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA-L2-type protocol to induce first complete remission. Twenty-one patients in first CR (median age 24 years, range 15-43), after receiving a conditioning regimen consisting of cyclophosphamide and total body irradiation, underwent autologous bone marrow transplantation. At this time fourtheen patients are alive and well 5-72 months post-transplant (median follow-up 58 months) with an actuarial disease free survival of 66%. These early results suggest that high-dose chemoradiotherapy followed by autologous bone marrow transplantation may improve long-term disease free survival in advanced stage adult lymphoblastic lymphoma.

Original language	English
Pages (from-to)	42-45
Number of pages	4
Journal	Leukemia
Volume	5
Issue number	SUPPL. 1
Publication status	Published - 1991

ASJC Scopus subject areas

Cancer Research
Hematology

Cite this

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title = "Autologous bone marrow transplantation for adult advanced stage lymphoblastic lymphoma in first CR. A study of the NHLCSG",

abstract = "Fourty successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA-L2-type protocol to induce first complete remission. Twenty-one patients in first CR (median age 24 years, range 15-43), after receiving a conditioning regimen consisting of cyclophosphamide and total body irradiation, underwent autologous bone marrow transplantation. At this time fourtheen patients are alive and well 5-72 months post-transplant (median follow-up 58 months) with an actuarial disease free survival of 66%. These early results suggest that high-dose chemoradiotherapy followed by autologous bone marrow transplantation may improve long-term disease free survival in advanced stage adult lymphoblastic lymphoma.",

author = "G. Santini and Congiu, {A. M.} and P. Coser and T. Chisesi and A. Porcellini and R. Sertoli and A. Contu and O. Vinante and D. Pierluigi and V. Vitale and A. Rubagotti and P. Orcamo and V. Rizzoli",

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AU - Santini, G.

AU - Congiu, A. M.

AU - Coser, P.

AU - Chisesi, T.

AU - Porcellini, A.

AU - Sertoli, R.

AU - Contu, A.

AU - Vinante, O.

AU - Pierluigi, D.

AU - Vitale, V.

AU - Rubagotti, A.

AU - Orcamo, P.

AU - Rizzoli, V.

PY - 1991

Y1 - 1991

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AB - Fourty successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA-L2-type protocol to induce first complete remission. Twenty-one patients in first CR (median age 24 years, range 15-43), after receiving a conditioning regimen consisting of cyclophosphamide and total body irradiation, underwent autologous bone marrow transplantation. At this time fourtheen patients are alive and well 5-72 months post-transplant (median follow-up 58 months) with an actuarial disease free survival of 66%. These early results suggest that high-dose chemoradiotherapy followed by autologous bone marrow transplantation may improve long-term disease free survival in advanced stage adult lymphoblastic lymphoma.

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Autologous bone marrow transplantation for adult advanced stage lymphoblastic lymphoma in first CR. A study of the NHLCSG

Abstract

ASJC Scopus subject areas

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